Seroatlas · Human Serome Atlas

ZNF208

Zinc finger protein 208

Also known as: PMIDP, ZN208_HUMAN, ZNF95

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43345
Gene
ZNF208
Ensembl
ENSG00000160321
Chromosome
19
Canonical length
1280 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

1280 residues, UniProt reviewed canonical sequence.

>O43345|ZNF208
     1  MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK
    61  ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV
   121  DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR
   181  SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK
   241  FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL
   301  TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK
   361  VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT
   421  GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSMFSILTK HKVIHNGEKP
   481  YKCEECDKAT HAGEKPYKCE ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL
   541  TKHKVIHTGE KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK
   601  RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS TLTTHKAIHA
   661  GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKRIHTGEKP
   721  YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW SSTLSYHKKI HTVEKPYKCE
   781  ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK
   841  AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM
   901  FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC GKAYKSSSTL
   961  SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP YKCEECGKAF NWSSNLMEHK
  1021  KIHTGETPYK CEECDKAFSW PSSLTEHKAT HAGEKPYKCE ECGKAFSWPS RLTEHKATHA
  1081  GEEPYKCEEC GKAFNWSSNL MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP
  1141  YKCEECGKAY KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE
  1201  ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE KPYKCEECGK
  1261  AFSWLSVFSK HKKIHTGEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF208 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 13 nTPM
  • heart muscle: 11 nTPM
  • hypothalamus: 8.7 nTPM
  • testis: 7.9 nTPM
  • midbrain: 7.7 nTPM
  • thyroid gland: 7.2 nTPM

Single-cell type

  • cardiomyocytes: 181 nCPM
  • renal connecting tubule cells: 168 nCPM
  • sertoli cells: 153 nCPM
  • pituicytes/fscs: 108 nCPM
  • renal collecting duct intercalated cells: 103 nCPM
  • renal collecting duct principal cells: 90 nCPM

Immune cell

  • neutrophil: 2.7 nTPM
  • basophil: 2.4 nTPM
  • plasmacytoid DC: 1.5 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • naive B-cell: 1.4 nTPM
  • T-reg: 1.4 nTPM

Brain region

  • medulla oblongata: 31 nTPM
  • pons: 31 nTPM
  • midbrain: 29 nTPM
  • hypothalamus: 27 nTPM
  • basal ganglia: 26 nTPM
  • thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0
gnomAD missense Z
-4.17
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF208 as an antibody target. Whether an autoantibody or antibody against ZNF208 could matter depends on whether native ZNF208 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF208 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF208 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF208. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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