Seroatlas · Human Serome Atlas

ZNF200

Zinc finger protein 200

Also known as: ZN200_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98182
Gene: ZNF200
Ensembl: ENSG00000010539
Chromosome: 16
Canonical length: 395 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in protein localization to nucleus. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>P98182|ZNF200
     1  MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF LTFLPKPSLV
    61  QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE QETVSLYLKA NPEELVVFED
   121  LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG EMMLLAVNGS NPEGEDPERE PVENEDYREK
   181  SSDDDEMDSS LVSQQPPDNQ EKERLNTSIP QKRKMRNLLV TIENDTPLEE LSKYVDISII
   241  ALTRNRRTRR WYTCPLCGKQ FNESSYLISH QRTHTGEKPY DCNHCGKSFN HKTNLNKHER
   301  IHTGEKPYSC SQCGKNFRQN SHRSRHEGIH IREKIFKCPE CGKTFPKNEE FVLHLQSHEA
   361  ERPYGCKKCG RRFGRLSNCT RHEKTHSACK TRKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF200 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
lymph node: 6.6 nTPM
tonsil: 6.2 nTPM
spleen: 6 nTPM
placenta: 5.9 nTPM
appendix: 5.5 nTPM

Single-cell type

late primary spermatocytes: 55 nCPM
early primary spermatocytes: 48 nCPM
neutrophils: 48 nCPM
early spermatids: 43 nCPM
differentiating spermatogonia: 39 nCPM
tuft cells: 35 nCPM

Immune cell

basophil: 32 nTPM
neutrophil: 22 nTPM
eosinophil: 19 nTPM
memory CD8 T-cell: 13 nTPM
T-reg: 12 nTPM
NK-cell: 12 nTPM

Brain region

cerebellum: 4.7 nTPM
cerebral cortex: 4.4 nTPM
hypothalamus: 3.5 nTPM
medulla oblongata: 3.5 nTPM
thalamus: 3.3 nTPM
spinal cord: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -1.49
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF200 as an antibody target. Whether an autoantibody or antibody against ZNF200 could matter depends on whether native ZNF200 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF200 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF200 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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