Seroatlas · Human Serome Atlas

ZNF20

Zinc finger protein 20

Also known as: KOX13, ZNF20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17024
Gene: ZNF20
Ensembl: ENSG00000132010
Chromosome: 19
Canonical length: 532 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>P17024|ZNF20
     1  MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW KVQNIEDEYK
    61  NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP GITPCESSVC GEVGTGHSSL
   121  NTHIRADTGH KSSEYQEYGE NPYRNKECKK AFSYLDSFQS HDKACTKEKP YDGKECTETF
   181  ISHSCIQRHR VMHSGDGPYK CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST
   241  TLPVHERTHT GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY
   301  HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC TSDLQRHEKT
   361  HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC GKVFKYFSSL RIHERTHTGE
   421  KPHECKQCGK AFRYFSSLHI HERTHTGDKP YECKVCGKAF TCSSSIRYHE RTHTGEKPYE
   481  CKHCGKAFIS NYIRYHERTH TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

testis: 5.9 nTPM
fallopian tube: 4.6 nTPM
thyroid gland: 3.2 nTPM
choroid plexus: 3 nTPM
epididymis: 2.9 nTPM
breast: 2.7 nTPM

Single-cell type

late spermatids: 69 nCPM
early spermatids: 50 nCPM
cardiomyocytes: 32 nCPM
respiratory ciliated cells: 31 nCPM
late primary spermatocytes: 30 nCPM
epididymal efferent duct ciliated cells: 26 nCPM

Immune cell

basophil: 12 nTPM
neutrophil: 11 nTPM
NK-cell: 6.7 nTPM
eosinophil: 3.6 nTPM
T-reg: 3.2 nTPM
naive B-cell: 2.5 nTPM

Brain region

choroid plexus: 7 nTPM
cerebellum: 5.8 nTPM
cerebral cortex: 4.6 nTPM
white matter: 4.6 nTPM
midbrain: 4.4 nTPM
pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.1
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF20 as an antibody target. Whether an autoantibody or antibody against ZNF20 could matter depends on whether native ZNF20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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