Seroatlas · Human Serome Atlas

ZNF2

Zinc finger protein 2

Also known as: A1-5, Zfp661, ZNF2_HUMAN, ZNF661

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSG1
Gene
ZNF2
Ensembl
ENSG00000275111
Chromosome
2
Canonical length
425 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q9BSG1|ZNF2
     1  MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI VSLGLPVPQP
    61  DVIFQLKRGD KPWMVDLHGS EEREWPESVS LDWETKPEIH DASDKKSEGS LRECLGRQSP
   121  LCPKFEVHTP NGRMGTEKQS PSGETRKKSL SRDKGLRRRS ALSREILTKE RHQECSDCGK
   181  TFFDHSSLTR HQRTHTGEKP YDCRECGKAF SHRSSLSRHL MSHTGESPYE CSVCSKAFFD
   241  RSSLTVHQRI HTGEKPFQCN ECGKAFFDRS SLTRHQRIHT GESPYECHQC GKAFSQKSIL
   301  TRHQLIHTGR KPYECNECGK AFYGVSSLNR HQKAHAGDPR YQCNECGKAF FDRSSLTQHQ
   361  KIHTGDKPYE CSECGKAFSQ RCRLTRHQRV HTGEKPFECT VCGKVFSSKS SVIQHQRRYA
   421  KQGID

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4 nTPM
  • parathyroid gland: 3.6 nTPM
  • tongue: 3.4 nTPM
  • epididymis: 3.1 nTPM
  • cervix: 3 nTPM
  • seminal vesicle: 3 nTPM

Single-cell type

  • cardiomyocytes: 46 nCPM
  • retinal horizontal cells: 18 nCPM
  • myonuclei: 16 nCPM
  • rod photoreceptor cells: 15 nCPM
  • adipocytes: 13 nCPM
  • differentiating spermatogonia: 13 nCPM

Immune cell

  • eosinophil: 13 nTPM
  • gdT-cell: 6.2 nTPM
  • naive CD4 T-cell: 6.1 nTPM
  • naive CD8 T-cell: 6 nTPM
  • T-reg: 6 nTPM
  • memory CD8 T-cell: 5.4 nTPM

Brain region

  • white matter: 6.7 nTPM
  • cerebellum: 6.2 nTPM
  • cerebral cortex: 5.9 nTPM
  • basal ganglia: 5.7 nTPM
  • medulla oblongata: 5.6 nTPM
  • pons: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.03
gnomAD missense Z
0.62
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF2 as an antibody target. Whether an autoantibody or antibody against ZNF2 could matter depends on whether native ZNF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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