Seroatlas · Human Serome Atlas

ZNF195

Zinc finger protein 195

Also known as: ZN195_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14628
Gene: ZNF195
Ensembl: ENSG00000005801
Chromosome: 11
Canonical length: 629 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>O14628|ZNF195
     1  MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP GLITCLEQRK
    61  EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS QSAGITGVNH RAQPGLNVSV
   121  DKFTALCSPG VLQTVKWFLE FRCIFSLAMS SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL
   181  DNLYLRKDWE SLDECKLQKD YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG
   241  EKPFKCQECG KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY
   301  KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE EKPCKYEECS
   361  SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH QRNEIGGKPF KCEECDSIFK
   421  WFSDLTKHKR IHTGEKPYKC DECGKAYTQS SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS
   481  LSNHKRTHSE EKPYTCEECG NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH
   541  KRIHTGEKPY KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH
   601  TGEKPYKCEK CGKAFTQFSH LTVHESIHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF195 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
thymus: 16 nTPM
epididymis: 15 nTPM
spleen: 14 nTPM
retina: 13 nTPM
breast: 13 nTPM

Single-cell type

gonadotrophs: 51 nCPM
choroid plexus epithelial cells: 47 nCPM
tuft cells: 46 nCPM
megakaryocyte-erythroid progenitors: 44 nCPM
thyrotrophs: 44 nCPM
oligodendrocytes: 43 nCPM

Immune cell

T-reg: 28 nTPM
naive CD8 T-cell: 20 nTPM
MAIT T-cell: 20 nTPM
memory CD8 T-cell: 20 nTPM
memory CD4 T-cell: 19 nTPM
memory B-cell: 19 nTPM

Brain region

pons: 16 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 16 nTPM
white matter: 15 nTPM
medulla oblongata: 15 nTPM
cerebellum: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 1.17
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF195 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF195 as an antibody target. Whether an autoantibody or antibody against ZNF195 could matter depends on whether native ZNF195 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF195 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF195 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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