Seroatlas · Human Serome Atlas

ZNF19

Zinc finger protein 19

Also known as: KOX12, MGC51021, ZNF19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17023
Gene: ZNF19
Ensembl: ENSG00000157429
Chromosome: 16
Canonical length: 458 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>P17023|ZNF19
     1  MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP
    61  ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL
   121  KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ
   181  RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS
   241  GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP
   301  YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV
   361  DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK
   421  AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
retina: 10 nTPM
skeletal muscle: 9 nTPM
choroid plexus: 8.7 nTPM
epididymis: 7.8 nTPM
fallopian tube: 7.8 nTPM

Single-cell type

ependymal cells: 224 nCPM
respiratory ciliated cells: 185 nCPM
choroid plexus epithelial cells: 152 nCPM
fallopian tube ciliated cells: 74 nCPM
cholangiocytes: 64 nCPM
somatotrophs: 61 nCPM

Immune cell

naive B-cell: 2.4 nTPM
basophil: 2.3 nTPM
memory B-cell: 2 nTPM
neutrophil: 1.6 nTPM
naive CD4 T-cell: 1.4 nTPM
naive CD8 T-cell: 1.4 nTPM

Brain region

cerebral cortex: 44 nTPM
white matter: 43 nTPM
choroid plexus: 41 nTPM
hippocampal formation: 39 nTPM
basal ganglia: 38 nTPM
cerebellum: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF19 as an antibody target. Whether an autoantibody or antibody against ZNF19 could matter depends on whether native ZNF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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