Seroatlas · Human Serome Atlas

ZNF185

Zinc finger protein 185

Also known as: SCELL, ZN185_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15231
Gene: ZNF185
Ensembl: ENSG00000147394
Chromosome: X
Canonical length: 689 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Focal adhesion sites,Cytosol

OverviewNCBI Gene

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>O15231|ZNF185
     1  MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG RTIELPSGRS
    61  RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ PQQQFPKANG TPKSAASLVR
   121  TANAGPPRPS SSGYKMTTED YKKLAPYNIR RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA
   181  ASGVLRRTAP REHSYVLSAA KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS
   241  TPGSNSADGG RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD
   301  VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV GSGATGSRPE
   361  GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD PKGALADYEG KDVATRVGEA
   421  WQERPGAPRG GQGDPAVPAQ QPADPSTPER QSSPSGSEQL VRRESCGSSV LTDFEGKDVA
   481  TKVGEAWQDR PGAPRGGQGD PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS
   541  SCMVTVTVTA TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV
   601  SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC CHEYCFKCGI
   661  CSKPMGDLLD QIFIHRDTIH CGKCYEKLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF185 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 317 nTPM

Expression across tissuesHPA

Tissue

esophagus: 317 nTPM
epididymis: 311 nTPM
seminal vesicle: 136 nTPM
vagina: 114 nTPM
cervix: 100 nTPM
skin: 51 nTPM

Single-cell type

esophageal apical cells: 1,653 nCPM
esophageal suprabasal cells: 529 nCPM
epididymal principal cells: 279 nCPM
platelets: 256 nCPM
suprabasal keratinocytes: 176 nCPM
somatotrophs: 159 nCPM

Immune cell

basophil: 49 nTPM
classical monocyte: 24 nTPM
intermediate monocyte: 22 nTPM
non-classical monocyte: 20 nTPM
total PBMC: 18 nTPM
neutrophil: 17 nTPM

Brain region

choroid plexus: 19 nTPM
cerebellum: 6 nTPM
hypothalamus: 5.9 nTPM
spinal cord: 5.7 nTPM
basal ganglia: 5.6 nTPM
white matter: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF185 as an antibody target. Whether an autoantibody or antibody against ZNF185 could matter depends on whether native ZNF185 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF185 is annotated at the cell surface, where native ZNF185 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZNF185 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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