Seroatlas · Human Serome Atlas

ZNF184

Zinc finger protein 184

Also known as: ZN184_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99676
Gene: ZNF184
Ensembl: ENSG00000096654
Chromosome: 6
Canonical length: 751 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

751 residues, UniProt reviewed canonical sequence.

>Q99676|ZNF184
     1  MEDLSSPDST LLQGGHNLLS SASFQEAVTF KDVIVDFTQE EWKQLDPGQR DLFRDVTLEN
    61  YTHLVSIGLQ VSKPDVISQL EQGTEPWIME PSIPVGTCAD WETRLENSVS APEPDISEEE
   121  LSPEVIVEKH KRDDSWSSNL LESWEYEGSL ERQQANQQTL PKEIKVTEKT IPSWEKGPVN
   181  NEFGKSVNVS SNLVTQEPSP EETSTKRSIK QNSNPVKKEK SCKCNECGKA FSYCSALIRH
   241  QRTHTGEKPY KCNECEKAFS RSENLINHQR IHTGDKPYKC DQCGKGFIEG PSLTQHQRIH
   301  TGEKPYKCDE CGKAFSQRTH LVQHQRIHTG EKPYTCNECG KAFSQRGHFM EHQKIHTGEK
   361  PFKCDECDKT FTRSTHLTQH QKIHTGEKTY KCNECGKAFN GPSTFIRHHM IHTGEKPYEC
   421  NECGKAFSQH SNLTQHQKTH TGEKPYDCAE CGKSFSYWSS LAQHLKIHTG EKPYKCNECG
   481  KAFSYCSSLT QHRRIHTREK PFECSECGKA FSYLSNLNQH QKTHTQEKAY ECKECGKAFI
   541  RSSSLAKHER IHTGEKPYQC HECGKTFSYG SSLIQHRKIH TGERPYKCNE CGRAFNQNIH
   601  LTQHKRIHTG AKPYECAECG KAFRHCSSLA QHQKTHTEEK PYQCNKCEKT FSQSSHLTQH
   661  QRIHTGEKPY KCNECDKAFS RSTHLTEHQN THTGEKPYNC NECRKTFSQS TYLIQHQRIH
   721  SGEKPFGCND CGKSFRYRSA LNKHQRLHPG I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF184 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

thymus: 9.3 nTPM
bone marrow: 8.2 nTPM
testis: 7.6 nTPM
kidney: 6.3 nTPM
ovary: 6 nTPM
tonsil: 6 nTPM

Single-cell type

late primary spermatocytes: 40 nCPM
tuft cells: 35 nCPM
early spermatids: 30 nCPM
somatotrophs: 17 nCPM
nk-cells: 16 nCPM
t-cells: 15 nCPM

Immune cell

MAIT T-cell: 11 nTPM
T-reg: 10 nTPM
memory CD4 T-cell: 8.4 nTPM
eosinophil: 8.1 nTPM
gdT-cell: 8 nTPM
naive CD8 T-cell: 7.9 nTPM

Brain region

cerebral cortex: 24 nTPM
hippocampal formation: 18 nTPM
basal ganglia: 16 nTPM
white matter: 12 nTPM
cerebellum: 8.9 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 2.51
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF184 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF184 as an antibody target. Whether an autoantibody or antibody against ZNF184 could matter depends on whether native ZNF184 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF184 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF184 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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