Seroatlas · Human Serome Atlas

ZNF180

Zinc finger protein 180

Also known as: HHZ168, ZN180_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJW8
Gene: ZNF180
Ensembl: ENSG00000167384
Chromosome: 19
Canonical length: 692 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

692 residues, UniProt reviewed canonical sequence.

>Q9UJW8|ZNF180
     1  MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK VCAQDSFLPQ EIIIKVEGED
    61  TGSLTIPSQE GVNFKIVTVD FTREEQGTCN PAQRTLDRDV ILENHRDLVS WDLATAVGKK
   121  DSTSKQRIFD EEPANGVKIE RFTRDDPWLS SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ
   181  RKAVIHERVC KSDETGEKSG LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN
   241  ENETLYENNE CGKPPQSIHL IQFTRTQTKD KSYGFSDRIQ SFCHGTPLHI HEKIHGGGKT
   301  FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE KPFECNQCGK
   361  SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ RTHTGEKPYR CNQCGKSFSQ
   421  SYVLVVHQRT HTGEKPYECN QCGKSFRQSY KLIAHQRTHT GEKPYECNQC GKSFIQSYKL
   481  IAHQRIHTGE KPYECNQCGK SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ
   541  RTHTGEKPYE CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT
   601  GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV HQRTHTGEKP
   661  FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF180 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 3.5 nTPM
retina: 2.4 nTPM
cerebellum: 2.1 nTPM
prostate: 2.1 nTPM
thyroid gland: 2.1 nTPM
adrenal gland: 1.9 nTPM

Single-cell type

thymic myoid cells: 22 nCPM
medullary thymic epithelial cells: 22 nCPM
cardiomyocytes: 19 nCPM
choroid plexus epithelial cells: 17 nCPM
adipocytes: 16 nCPM
thyrotrophs: 16 nCPM

Immune cell

T-reg: 2.7 nTPM
basophil: 1.7 nTPM
memory B-cell: 1.6 nTPM
myeloid DC: 1.2 nTPM
naive CD4 T-cell: 1.2 nTPM
eosinophil: 1.1 nTPM

Brain region

cerebellum: 2.7 nTPM
choroid plexus: 2.5 nTPM
cerebral cortex: 2 nTPM
pons: 1.9 nTPM
white matter: 1.8 nTPM
basal ganglia: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF180 as an antibody target. Whether an autoantibody or antibody against ZNF180 could matter depends on whether native ZNF180 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF180 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF180 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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