ZNF175
Zinc finger protein 175
Also known as: OTK18, ZN175_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y473
- Gene
- ZNF175
- Ensembl
- ENSG00000105497
- Chromosome
- 19
- Canonical length
- 711 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
711 residues, UniProt reviewed canonical sequence.
>Q9Y473|ZNF175
1 MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC LYRDVMLELY
61 SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER EFGLEIPQKE ISKKASFQKD
121 MVGEFTRDGS WCSILEELRL DADRTKKDEQ NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK
181 MIRTRPHLAS SQKQPQKCCL FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA
241 CSKNIHTGET FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI
301 HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL LTHQKTHTRK
361 KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF SQNSTLIIHQ KIHTGERQYA
421 CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC
481 GKSFISKSQL DIHHRIHTGE KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF
541 NQKSILSMHQ RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS
601 NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK SFSKKPQLKV
661 HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK CSYSVKGFTK QLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF175 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 10 nTPM
Expression across tissuesHPA
Tissue
- retina: 10 nTPM
- testis: 9.5 nTPM
- parathyroid gland: 9.4 nTPM
- cerebellum: 7.7 nTPM
- placenta: 7.5 nTPM
- ovary: 6.8 nTPM
Single-cell type
- retinal horizontal cells: 40 nCPM
- platelets: 34 nCPM
- thyrotrophs: 29 nCPM
- choroid plexus epithelial cells: 21 nCPM
- early spermatids: 21 nCPM
- lactotrophs: 20 nCPM
Immune cell
- plasmacytoid DC: 1.4 nTPM
- naive CD4 T-cell: 0.6 nTPM
- MAIT T-cell: 0.5 nTPM
- memory B-cell: 0.5 nTPM
- memory CD4 T-cell: 0.5 nTPM
- naive B-cell: 0.5 nTPM
Brain region
- cerebellum: 32 nTPM
- choroid plexus: 23 nTPM
- white matter: 22 nTPM
- thalamus: 21 nTPM
- cerebral cortex: 19 nTPM
- basal ganglia: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- defense response to virus
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF175 as an antibody target. Whether an autoantibody or antibody against ZNF175 could matter depends on whether native ZNF175 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF175 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF175 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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