Seroatlas · Human Serome Atlas

ZNF17

Zinc finger protein 17

Also known as: FLJ40864, FLJ46058, FLJ46615, HPF3, KIAA1947, KOX10, ZNF17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17021
Gene: ZNF17
Ensembl: ENSG00000186272
Chromosome: 19
Canonical length: 662 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>P17021|ZNF17
     1  MNLTEDYMVF EDVAIHFSQE EWGILNDVQR HLHSDVMLEN FALLSSVGCW HGAKDEEAPS
    61  KQCVSVGVSQ VTTLKPALST QKAQPCETCS SLLKDILHLA EHDGTHPKRT AKLYLHQKEH
   121  LREKLTRSDE GRPSFVNDSV HLAKRNLTCM QGGKDFTGDS DLQQQALHSG WKPHRDTHGV
   181  EAFQSGQNNY SCTQCGKDFC HQHTLFEHQK IHTEERPYEC SECGKLFRYN SDLIKHQRNH
   241  TGERPYKCSE CGKAFSLKYN VVQHQKIHTG ERPYECSECG KAFLRKSHLL QHQRIHTRPR
   301  PYVCSECGKA FLTQAHLVGH QKIHTGERPY GCNECGKYFM YSSALIRHQK VHTGERPFYC
   361  CECGKFFMDS CTLIIHQRVH TGEKPYECNE CGKFFRYRST LIRHQKVHTG EKPYECSECG
   421  KFFMDTSTLI IHQRVHTGEK PYECNKCGKF FRYCFTLNRH QRVHSGERPY ECSECGKFFV
   481  DSCTLKSHQR VHTGERPFEC SICGKSFRCR STLDTHQRIH TGERPYECSE CGKFFRHNSN
   541  HIRHRRNHFG ERSFECTECG RVFSQNSHLI RHQKVHTRER TYKCSKCGKF FMDSSTLISH
   601  ERVHTGEKPY ECSECGKVFR YNSSLIKHRR IHTGERPYQC SECGRVFNQN SHLIQHQKVH
   661  TR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

retina: 8.1 nTPM
tongue: 5.9 nTPM
ovary: 5.6 nTPM
thymus: 5.6 nTPM
breast: 5 nTPM
thyroid gland: 4.8 nTPM

Single-cell type

adipocytes: 0.8 nCPM
thymocytes: 0.8 nCPM
prostatic club cells: 0.5 nCPM
cardiomyocytes: 0.4 nCPM
basal prostatic cells: 0.3 nCPM
fibro-adipogenic progenitors: 0.3 nCPM

Immune cell

NK-cell: 6.4 nTPM
naive CD4 T-cell: 5.8 nTPM
MAIT T-cell: 5.1 nTPM
memory CD8 T-cell: 5.1 nTPM
naive B-cell: 4.7 nTPM
memory CD4 T-cell: 4.5 nTPM

Brain region

cerebellum: 23 nTPM
white matter: 19 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 16 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0.23
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF17 as an antibody target. Whether an autoantibody or antibody against ZNF17 could matter depends on whether native ZNF17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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