Seroatlas · Human Serome Atlas

ZNF160

Zinc finger protein 160

Also known as: F11, FLJ00032, HKr18, HZF5, KIAA1611, KR18, ZN160_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCG1
Gene: ZNF160
Ensembl: ENSG00000170949
Chromosome: 19
Canonical length: 818 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

818 residues, UniProt reviewed canonical sequence.

>Q9HCG1|ZNF160
     1  MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC HFDMNIISML
    61  EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD LLPKEKSSTE AVFHTVVLER
   121  HESPDIEDFS FKEPQKNVHD FECQWRDDTG NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ
   181  LGVSFHSHLP ELQLFQGEGK MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH
   241  FSLLTQRRKA NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL
   301  TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF RGHSNLTTHQ
   361  LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN ECGKAFSVRS SLAIHQTIHT
   421  GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE KPYKCNECGK AFSMHSNLAT HQVIHTGTKP
   481  FKCNECSKVF TQNSQLANHR RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI
   541  ECGKSFTQKS HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR
   601  AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK CNECGKAFSM
   661  HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT GEKPYRCNEC GKAFSVRSSL
   721  TTHQAIHTGK KPYKCNECGK VFTQNAHLAN HRRIHTGEKP YRCTECGKAF RVRSSLTTHM
   781  AIHTGEKRYK CNECGKVFRQ SSNLASHHRM HTGEKPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

spleen: 29 nTPM
adrenal gland: 26 nTPM
thyroid gland: 25 nTPM
kidney: 18 nTPM
ovary: 17 nTPM
endometrium: 16 nTPM

Single-cell type

adrenal cortex cells: 125 nCPM
sertoli cells: 123 nCPM
granulosa cells: 93 nCPM
proximal tubule cells: 67 nCPM
vascular endothelial cells: 64 nCPM
renal collecting duct intercalated cells: 63 nCPM

Immune cell

NK-cell: 18 nTPM
basophil: 11 nTPM
eosinophil: 10 nTPM
MAIT T-cell: 9.7 nTPM
naive CD4 T-cell: 9.3 nTPM
memory CD8 T-cell: 8.2 nTPM

Brain region

white matter: 34 nTPM
cerebellum: 27 nTPM
cerebral cortex: 25 nTPM
medulla oblongata: 24 nTPM
pons: 24 nTPM
hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0.03
gnomAD missense Z: 1.49
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF160 as an antibody target. Whether an autoantibody or antibody against ZNF160 could matter depends on whether native ZNF160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF160 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF160 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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