ZNF157
Zinc finger protein 157
Also known as: HZF22, ZN157_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P51786
- Gene
- ZNF157
- Ensembl
- ENSG00000147117
- Chromosome
- X
- Canonical length
- 506 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
506 residues, UniProt reviewed canonical sequence.
>P51786|ZNF157
1 MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT MHKDVMLETY
61 SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS LSLLCGNGSV GDNALRHDND
121 LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV RRKRTPRGDK NFECHECGKA YCRKSNLVEH
181 LRIHTGERPY ECGECAKTFS ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH
241 TGERPYECTE CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK
301 PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR THTGEKPYQC
361 NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR LIEHQRMHSG EKPYECSECG
421 KIFSMKKSLC QHRRTHTGEK PYECSECGNA FYVKVRLIEH QRIHTGERPF ECQECGKAFC
481 RKAHLTEHQR THIGWSWRCT MKKASHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF157 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 1.3 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 1.3 nTPM
- fallopian tube: 1.1 nTPM
- cerebellum: 1 nTPM
- retina: 1 nTPM
- pituitary gland: 0.9 nTPM
- parathyroid gland: 0.6 nTPM
Single-cell type
- thyrotrophs: 10 nCPM
- fallopian tube ciliated cells: 9.8 nCPM
- retinal amacrine cells: 9.8 nCPM
- corticotrophs: 9.3 nCPM
- somatotrophs: 7.9 nCPM
- respiratory ciliated cells: 7.8 nCPM
Immune cell
- naive CD4 T-cell: 0.4 nTPM
- memory CD8 T-cell: 0.3 nTPM
- naive CD8 T-cell: 0.3 nTPM
- memory B-cell: 0.2 nTPM
- basophil: 0.1 nTPM
- naive B-cell: 0.1 nTPM
Brain region
- cerebellum: 7.5 nTPM
- cerebral cortex: 3.1 nTPM
- hypothalamus: 3.1 nTPM
- white matter: 3.1 nTPM
- basal ganglia: 3 nTPM
- amygdala: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.32
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.31
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF157 as an antibody target. Whether an autoantibody or antibody against ZNF157 could matter depends on whether native ZNF157 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF157 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF157 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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