Seroatlas · Human Serome Atlas

ZNF154

Zinc finger protein 154

Also known as: pHZ-92, ZN154_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13106
Gene: ZNF154
Ensembl: ENSG00000179909
Chromosome: 19
Canonical length: 437 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q13106|ZNF154
     1  MAAATLRTPT QGTVTFEDVA VHFSWEEWGL LDEAQRCLYR DVMLENLALL TSLDVHHQKQ
    61  HLGEKHFRSN VGRALFVKTC TFHVSGEPST CREVGKDFLA KLGFLHQQAA HTGEQSNSKS
   121  DGGAISHRGK THYNCGEHTK AFSGKHTLVQ QQRTLTTERC YICSECGKSF SKSYSLNDHW
   181  RLHTGEKPYE CRECGKSFRQ SSSLIQHRRV HTAVRPHECD ECGKLFSNKS NLIKHRRVHT
   241  GERPYECSEC GKSFSQRSAL LQHRGVHTGE RPYECSECGK FFTYHSSLIK HQKVHSGSRP
   301  YECSECGKSF SQNSSLIEHH RVHTGERPYK CSECGKSFSQ RSALLQHRGV HTGERPYECS
   361  ECGKFFPYSS SLRKHQRVHT GSRPYECSEC GKSFTQNSGL IKHRRVHTGE KPYECTECGK
   421  SFSHNSSLIK HQRIHSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF154 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

thymus: 5.7 nTPM
thyroid gland: 4.6 nTPM
lymph node: 4.5 nTPM
retina: 4.3 nTPM
spleen: 4.3 nTPM
tonsil: 4 nTPM

Single-cell type

cardiomyocytes: 84 nCPM
epicardial cells: 25 nCPM
somatotrophs: 24 nCPM
choroid plexus epithelial cells: 23 nCPM
lactotrophs: 20 nCPM
thyrotrophs: 19 nCPM

Immune cell

eosinophil: 2.1 nTPM
naive B-cell: 1 nTPM
basophil: 0.9 nTPM
MAIT T-cell: 0.6 nTPM
neutrophil: 0.6 nTPM
memory B-cell: 0.5 nTPM

Brain region

cerebellum: 22 nTPM
choroid plexus: 19 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
hippocampal formation: 14 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF154 as an antibody target. Whether an autoantibody or antibody against ZNF154 could matter depends on whether native ZNF154 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF154 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF154 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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