ZNF141
Zinc finger protein 141
Also known as: D4S90, pHZ-44, ZN141_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15928
- Gene
- ZNF141
- Ensembl
- ENSG00000131127
- Chromosome
- 4
- Canonical length
- 474 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
Canonical amino-acid sequenceUniProt
474 residues, UniProt reviewed canonical sequence.
>Q15928|ZNF141
1 MELLTFRDVA IEFSPEEWKC LDPDQQNLYR DVMLENYRNL VSLGVAISNP DLVTCLEQRK
61 EPYNVKIHKI VARPPAMCSH FTQDHWPVQG IEDSFHKLIL RRYEKCGHDN LQLRKGCKSL
121 NECKLQKGGY NEFNECLSTT QSKILQCKAS VKVVSKFSNS NKRKTRHTGE KHFKECGKSF
181 QKFSHLTQHK VIHAGEKPYT CEECGKAFKW SLIFNEHKRI HTGEKPFTCE ECGSIFTTSS
241 HFAKHKIIHT GEKPYKCEEC GKAFNRFTTL TKHKRIHAGE KPITCEECRK IFTSSSNFAK
301 HKRIHTGEKP YKCEECGKAF NRSTTLTKHK RIHTGEKPYT CEECGKAFRQ SSKLNEHKKV
361 HTGERPYKCD ECGKAFGRSR VLNEHKKIHT GEKPYKCEEC GKAFRRSTDR SQHKKIHSAD
421 KPYKCKECDK AFKQFSLLSQ HKKIHTVDKP YKCKDCDKAF KRFSHLNKHK KIHTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 13 nTPM
- cerebellum: 13 nTPM
- retina: 13 nTPM
- ovary: 11 nTPM
- basal ganglia: 7 nTPM
- pituitary gland: 6.9 nTPM
Single-cell type
- vascular smooth muscle cells: 187 nCPM
- innate lymphoid cells: 108 nCPM
- b-cells: 106 nCPM
- somatotrophs: 106 nCPM
- granulosa cells: 92 nCPM
- lactotrophs: 87 nCPM
Immune cell
- naive B-cell: 1.8 nTPM
- naive CD4 T-cell: 1.6 nTPM
- gdT-cell: 1.3 nTPM
- MAIT T-cell: 1.3 nTPM
- naive CD8 T-cell: 1.3 nTPM
- NK-cell: 1.3 nTPM
Brain region
- cerebellum: 19 nTPM
- cerebral cortex: 13 nTPM
- basal ganglia: 12 nTPM
- choroid plexus: 12 nTPM
- white matter: 12 nTPM
- hippocampal formation: 12 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ZNF141.
Disease | AllUniProt
Conditions ZNF141 is implicated in, by any mechanism.
- Polydactyly, postaxial A6 (PAPA6) MIM:615226
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 92 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Polydactyly, postaxial, type A6
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 0.22
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anatomical structure morphogenesis
- limb morphogenesis
- negative regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF141 as an antibody target. Whether an autoantibody or antibody against ZNF141 could matter depends on whether native ZNF141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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