Seroatlas · Human Serome Atlas

ZNF140

Zinc finger protein 140

Also known as: pHZ-39, ZN140_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52738
Gene: ZNF140
Ensembl: ENSG00000196387
Chromosome: 12
Canonical length: 457 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>P52738|ZNF140
     1  MSQGSVTFRD VAIDFSQEEW KWLQPAQRDL YRCVMLENYG HLVSLGLSIS KPDVVSLLEQ
    61  GKEPWLGKRE VKRDLFSVSE SSGEIKDFSP KNVIYDDSSQ YLIMERILSQ GPVYSSFKGG
   121  WKCKDHTEML QENQGCIRKV TVSHQEALAQ HMNISTVERP YGCHECGKTF GRRFSLVLHQ
   181  RTHTGEKPYA CKECGKTFSQ ISNLVKHQMI HTGKKPHECK DCNKTFSYLS FLIEHQRTHT
   241  GEKPYECTEC GKAFSRASNL TRHQRIHIGK KQYICRKCGK AFSSGSELIR HQITHTGEKP
   301  YECIECGKAF RRFSHLTRHQ SIHTTKTPYE CNECRKAFRC HSFLIKHQRI HAGEKLYECD
   361  ECGKVFTWHA SLIQHTKSHT GEKPYACAEC DKAFSRSFSL ILHQRTHTGE KPYVCKVCNK
   421  SFSWSSNLAK HQRTHTLDNP YEYENSFNYH SFLTEHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF140 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 14 nTPM
ovary: 13 nTPM
thyroid gland: 12 nTPM
cerebellum: 11 nTPM
prostate: 11 nTPM
endometrium: 11 nTPM

Single-cell type

cardiomyocytes: 66 nCPM
somatotrophs: 56 nCPM
epicardial cells: 55 nCPM
lactotrophs: 54 nCPM
choroid plexus epithelial cells: 38 nCPM
gonadotrophs: 37 nCPM

Immune cell

naive CD4 T-cell: 22 nTPM
T-reg: 19 nTPM
NK-cell: 19 nTPM
eosinophil: 19 nTPM
MAIT T-cell: 19 nTPM
memory B-cell: 18 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 21 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 20 nTPM
choroid plexus: 20 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF140 as an antibody target. Whether an autoantibody or antibody against ZNF140 could matter depends on whether native ZNF140 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF140 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF140 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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