ZNF138
Zinc finger protein 138
Also known as: pHZ-32, ZN138_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P52744
- Gene
- ZNF138
- Ensembl
- ENSG00000197008
- Chromosome
- 7
- Canonical length
- 262 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
262 residues, UniProt reviewed canonical sequence.
>P52744|ZNF138
1 MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL RKGCKSVDEC
61 KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH KIRHTENKHF RCKECDKSLC
121 MLSRLTQHKK IHTRENFYKC EECGKTFNWS TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI
181 LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH
241 QIIYTGEEPY KCEECGKAFN LSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF138 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 6.9 nTPM
Expression across tissuesHPA
Tissue
- breast: 6.9 nTPM
- skin: 6.8 nTPM
- spinal cord: 6.1 nTPM
- lymph node: 5.4 nTPM
- tonsil: 5.2 nTPM
- cerebral cortex: 5.1 nTPM
Single-cell type
- myonuclei: 129 nCPM
- gonadotrophs: 74 nCPM
- brain inhibitory neurons: 72 nCPM
- breast lactating cells: 72 nCPM
- oligodendrocytes: 70 nCPM
- brain excitatory neurons: 68 nCPM
Immune cell
- basophil: 12 nTPM
- memory B-cell: 7.4 nTPM
- naive B-cell: 7.4 nTPM
- naive CD4 T-cell: 6.6 nTPM
- memory CD8 T-cell: 6.3 nTPM
- naive CD8 T-cell: 6.3 nTPM
Brain region
- cerebellum: 31 nTPM
- white matter: 29 nTPM
- cerebral cortex: 27 nTPM
- pons: 24 nTPM
- midbrain: 24 nTPM
- basal ganglia: 24 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0.05
- gnomAD missense Z
- -0.25
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF138 as an antibody target. Whether an autoantibody or antibody against ZNF138 could matter depends on whether native ZNF138 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF138 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF138 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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