Seroatlas · Human Serome Atlas

ZNF135

Zinc finger protein 135

Also known as: pHZ-17, ZN135_HUMAN, ZNF61, ZNF78L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52742
Gene: ZNF135
Ensembl: ENSG00000176293
Chromosome: 19
Canonical length: 658 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

658 residues, UniProt reviewed canonical sequence.

>P52742|ZNF135
     1  MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL VSVGHWLPKP
    61  NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ GISEEISNSV ILVERFLWDG
   121  LWYCRGEDTE GHWEWSCESL ESLAVPVAFT PVKTPVLEQW QRNGFGENIS LNPDLPHQPM
   181  TPERQSPHTW GTRGKREKPD LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER
   241  PYECHECLKG FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC
   301  SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG EKPYQCGECG
   361  KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH QRTHTGEKPY ECGECGKAFS
   421  QSTLLTEHRR IHTGEKPYGC NECGKTFSHS SSLSQHERTH TGEKPYECSQ CGKAFRQSTH
   481  LTQHQRIHTG EKPYECNDCG KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH
   541  QRIHTGEKPY ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH
   601  TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT KHQRTHTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF135 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

ovary: 11 nTPM
parathyroid gland: 10 nTPM
retina: 9.2 nTPM
endometrium: 8.2 nTPM
pituitary gland: 7.6 nTPM
epididymis: 7.5 nTPM

Single-cell type

cardiomyocytes: 124 nCPM
oligodendrocytes: 55 nCPM
epicardial cells: 55 nCPM
retinal horizontal cells: 50 nCPM
distal convoluted tubule cells: 46 nCPM
choroid plexus epithelial cells: 44 nCPM

Immune cell

NK-cell: 2.6 nTPM
plasmacytoid DC: 2 nTPM
eosinophil: 1.9 nTPM
naive CD4 T-cell: 1.8 nTPM
naive B-cell: 1.7 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

white matter: 19 nTPM
amygdala: 14 nTPM
basal ganglia: 14 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF135 as an antibody target. Whether an autoantibody or antibody against ZNF135 could matter depends on whether native ZNF135 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF135 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF135 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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