Seroatlas · Human Serome Atlas

ZNF133

Zinc finger protein 133

Also known as: pHZ-13, pHZ-66, ZN133_HUMAN, ZNF150

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52736
Gene: ZNF133
Ensembl: ENSG00000125846
Chromosome: 20
Canonical length: 654 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

654 residues, UniProt reviewed canonical sequence.

>P52736|ZNF133
     1  MAFRDVAVDF TQDEWRLLSP AQRTLYREVM LENYSNLVSL GISFSKPELI TQLEQGKETW
    61  REEKKCSPAT CPADPEPELY LDPFCPPGFS SQKFPMQHVL CNHPPWIFTC LCAEGNIQPG
   121  DPGPGDQEKQ QQASEGRPWS DQAEGPEGEG AMPLFGRTKK RTLGAFSRPP QRQPVSSRNG
   181  LRGVELEASP AQSGNPEETD KLLKRIEVLG FGTVNCGECG LSFSKMTNLL SHQRIHSGEK
   241  PYVCGVCEKG FSLKKSLARH QKAHSGEKPI VCRECGRGFN RKSTLIIHER THSGEKPYMC
   301  SECGRGFSQK SNLIIHQRTH SGEKPYVCRE CGKGFSQKSA VVRHQRTHLE EKTIVCSDCG
   361  LGFSDRSNLI SHQRTHSGEK PYACKECGRC FRQRTTLVNH QRTHSKEKPY VCGVCGHSFS
   421  QNSTLISHRR THTGEKPYVC GVCGRGFSLK SHLNRHQNIH SGEKPIVCKD CGRGFSQQSN
   481  LIRHQRTHSG EKPMVCGECG RGFSQKSNLV AHQRTHSGER PYVCRECGRG FSHQAGLIRH
   541  KRKHSREKPY MCRQCGLGFG NKSALITHKR AHSEEKPCVC RECGQGFLQK SHLTLHQMTH
   601  TGEKPYVCKT CGRGFSLKSH LSRHRKTTSV HHRLPVQPDP EPCAGQPSDS LYSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF133 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 29 nTPM
cerebellum: 28 nTPM
pituitary gland: 21 nTPM
prostate: 18 nTPM
kidney: 18 nTPM
ovary: 17 nTPM

Single-cell type

choroid plexus epithelial cells: 179 nCPM
thyrotrophs: 86 nCPM
somatotrophs: 78 nCPM
lactotrophs: 73 nCPM
gonadotrophs: 69 nCPM
fibro-adipogenic progenitors: 66 nCPM

Immune cell

NK-cell: 8.2 nTPM
gdT-cell: 5.7 nTPM
memory CD4 T-cell: 4.8 nTPM
naive CD8 T-cell: 4.4 nTPM
T-reg: 4 nTPM
MAIT T-cell: 3.9 nTPM

Brain region

choroid plexus: 19 nTPM
cerebellum: 16 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 2.01
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF133 as an antibody target. Whether an autoantibody or antibody against ZNF133 could matter depends on whether native ZNF133 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF133 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF133 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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