ZNF132
Zinc finger protein 132
Also known as: pHZ-12, ZN132_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P52740
- Gene
- ZNF132
- Ensembl
- ENSG00000131849
- Chromosome
- 19
- Canonical length
- 706 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Vesicles,Intermediate filaments
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
706 residues, UniProt reviewed canonical sequence.
>P52740|ZNF132
1 MALPSPQVLM GLPALLMGPA QHTSWPCGSA VPTLKSMVTF EDVAVYFSQE EWELLDAAQR
61 HLYHSVMLEN LELVTSLGSW HGVEGEGAHP KQNVSVEVLQ VRIPNADPST KKANSCDMCG
121 PFLKDILHLA EHQGTQSEEK PYTCGACGRD FWLNANLHQH QKEHSGGKPF RWYKDRDALM
181 KSSKVHLSEN PFTCREGGKV ILGSCDLLQL QAVDSGQKPY SNLGQLPEVC TTQKLFECSN
241 CGKAFLKSST LPNHLRTHSE EIPFTCPTGG NFLEEKSILG NKKFHTGEIP HVCKECGKAF
301 SHSSKLRKHQ KFHTEVKYYE CIACGKTFNH KLTFVHHQRI HSGERPYECD ECGKAFSNRS
361 HLIRHEKVHT GERPFECLKC GRAFSQSSNF LRHQKVHTQV RPYECSQCGK SFSRSSALIQ
421 HWRVHTGERP YECSECGRAF NNNSNLAQHQ KVHTGERPFE CSECGRDFSQ SSHLLRHQKV
481 HTGERPFECC DCGKAFSNSS TLIQHQKVHT GQRPYECSEC RKSFSRSSSL IQHWRIHTGE
541 KPYECSECGK AFAHSSTLIE HWRVHTKERP YECNECGKFF SQNSILIKHQ KVHTGEKPYK
601 CSECGKFFSR KSSLICHWRV HTGERPYECS ECGRAFSSNS HLVRHQRVHT QERPYECIQC
661 GKAFSERSTL VRHQKVHTRE RTYECSQCGK LFSHLCNLAQ HKKIHTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF132 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 8 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 8 nTPM
- thyroid gland: 4.4 nTPM
- fallopian tube: 3.4 nTPM
- pituitary gland: 3.4 nTPM
- testis: 3.1 nTPM
- ovary: 3 nTPM
Single-cell type
- cardiomyocytes: 29 nCPM
- epicardial cells: 11 nCPM
- rod photoreceptor cells: 8.6 nCPM
- late primary spermatocytes: 8.3 nCPM
- lactotrophs: 7.9 nCPM
- choroid plexus epithelial cells: 6.3 nCPM
Immune cell
- MAIT T-cell: 2.1 nTPM
- naive CD4 T-cell: 1.6 nTPM
- naive B-cell: 1.3 nTPM
- naive CD8 T-cell: 1.3 nTPM
- NK-cell: 1.2 nTPM
- myeloid DC: 1.1 nTPM
Brain region
- choroid plexus: 11 nTPM
- cerebellum: 11 nTPM
- cerebral cortex: 7.5 nTPM
- white matter: 7.3 nTPM
- midbrain: 7.2 nTPM
- hypothalamus: 6.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.28
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.6
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- positive regulation of biosynthetic process
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF132 as an antibody target. Whether an autoantibody or antibody against ZNF132 could matter depends on whether native ZNF132 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF132 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF132 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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