Seroatlas · Human Serome Atlas

ZNF124

Zinc finger protein 124

Also known as: HZF-16, HZF16, ZN124_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15973
Gene: ZNF124
Ensembl: ENSG00000196418
Chromosome: 1
Canonical length: 351 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q15973|ZNF124
     1  MSGHPGSWEM NSVAFEDVAV NFTQEEWALL DPSQKNLYRD VMQETFRNLA SIGNKGEDQS
    61  IEDQYKNSSR NLRHIISHSG NNPYGCEECG KKPCTCKQCQ KTSLSVTRVH RDTVMHTGNG
   121  HYGCTICEKV FNIPSSFQIH QRNHTGEKPY ECMECGKALG FSRSLNRHKR IHTGEKRYEC
   181  KQCGKAFSRS SHLRDHERTH TGEKPYECKH CGKAFRYSNC LHYHERTHTG EKPYVCMECG
   241  KAFSCLSSLQ GHIKAHAGEE PYPCKQCGKA FRYASSLQKH EKTHIAQKPY VCNNCGKGFR
   301  CSSSLRDHER THTGEKPYEC QKCGKAFSRA STLWKHKKTH TGEKPYKCKK M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF124 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

colon: 5.8 nTPM
thymus: 5.7 nTPM
rectum: 5.3 nTPM
duodenum: 5.2 nTPM
small intestine: 5 nTPM
lymph node: 4.9 nTPM

Single-cell type

late spermatids: 1,606 nCPM
early spermatids: 439 nCPM
kupffer cells: 156 nCPM
epicardial cells: 143 nCPM
podocytes: 141 nCPM
thymocytes: 119 nCPM

Immune cell

non-classical monocyte: 13 nTPM
myeloid DC: 9.7 nTPM
naive CD4 T-cell: 8.6 nTPM
NK-cell: 8.6 nTPM
eosinophil: 8.5 nTPM
naive CD8 T-cell: 8.4 nTPM

Brain region

cerebellum: 50 nTPM
hypothalamus: 38 nTPM
white matter: 38 nTPM
pons: 37 nTPM
thalamus: 36 nTPM
cerebral cortex: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0.01
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF124 as an antibody target. Whether an autoantibody or antibody against ZNF124 could matter depends on whether native ZNF124 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF124 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF124 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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