Seroatlas · Human Serome Atlas

ZNF121

Zinc finger protein 121

Also known as: D19S204, ZHC32, ZN121_HUMAN, ZNF20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58317
Gene: ZNF121
Ensembl: ENSG00000197961
Chromosome: 19
Canonical length: 390 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>P58317|ZNF121
     1  MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM LHNSAPAGET
    61  LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ SHLQANRITH NGETLYEQKQ
   121  CGRAFTYSTS HAVSVKMHTV EKPYECKECG KFFRYSSYLN SHMRTHTGEK PYECKECGKC
   181  FTVSSHLVEH VRIHTGEKPY QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF
   241  YLLTEHFKTH TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH
   301  NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR ASSHLQKHVR
   361  IHTGEKPYIC NECGKAYNRF YLLTKHLKTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF121 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
skin: 9.4 nTPM
esophagus: 8.2 nTPM
parathyroid gland: 8.1 nTPM
liver: 7.8 nTPM
spleen: 6.9 nTPM

Single-cell type

urothelial cells: 82 nCPM
ocular epithelial cells: 73 nCPM
megakaryocyte-erythroid progenitors: 68 nCPM
erythrocyte progenitors: 60 nCPM
esophageal apical cells: 56 nCPM
esophageal suprabasal cells: 49 nCPM

Immune cell

NK-cell: 3.1 nTPM
MAIT T-cell: 2.8 nTPM
naive CD8 T-cell: 2.6 nTPM
naive B-cell: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM
gdT-cell: 2.1 nTPM

Brain region

white matter: 30 nTPM
cerebellum: 30 nTPM
choroid plexus: 29 nTPM
hypothalamus: 26 nTPM
thalamus: 25 nTPM
cerebral cortex: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0.39
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF121 as an antibody target. Whether an autoantibody or antibody against ZNF121 could matter depends on whether native ZNF121 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF121 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF121 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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