Seroatlas · Human Serome Atlas

ZNF12

Zinc finger protein 12

Also known as: GIOT-3, KOX3, ZNF12_HUMAN, ZNF325

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17014
Gene: ZNF12
Ensembl: ENSG00000164631
Chromosome: 7
Canonical length: 697 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>P17014|ZNF12
     1  MNKSLGPVSF KDVAVDFTQE EWQQLDPEQK ITYRDVMLEN YSNLVSVGYH IIKPDVISKL
    61  EQGEEPWIVE GEFLLQSYPD EVWQTDDLIE RIQEEENKPS RQTVFIETLI EERGNVPGKT
   121  FDVETNPVPS RKIAYKNSLC DSCEKCLTSV SEYISSDGSY ARMKADECSG CGKSLLHIKL
   181  EKTHPGDQAY EFNQNGEPYT LNEESLYQKI RILEKPFEYI ECQKAFQKDT VFVNHMEEKP
   241  YKWNGSEIAF LQMSDLTVHQ TSHMEMKPYE CSECGKSFCK KSKFIIHQRT HTGEKPYECN
   301  QCGKSFCQKG TLTVHQRTHT GEKPYECNEC GKNFYQKLHL IQHQRTHSGE KPYECSYCGK
   361  SFCQKTHLTQ HQRTHSGERP YVCHDCGKTF SQKSALNDHQ KIHTGVKLYK CSECGKCFCR
   421  KSTLTTHLRT HTGEKPYECN ECGKFFSRLS YLTVHYRTHS GEKPYECNEC GKTFYLNSAL
   481  MRHQRVHTGE KPYECNECGK LFSQLSYLTI HHRTHSGVKP YECSECGKTF YQNSALCRHR
   541  RIHKGEKPYE CYICGKFFSQ MSYLTIHHRI HSGEKPYECS ECGKTFCQNS ALNRHQRTHT
   601  GEKAYECYEC GKCFSQMSYL TIHHRIHSGE KPFECNECGK AFSRMSYLTV HYRTHSGEKP
   661  YECTECGKKF YHKSAFNSHQ RIHRRGNMNV IDVGRLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 17 nTPM
retina: 14 nTPM
epididymis: 13 nTPM
thyroid gland: 13 nTPM
endometrium: 13 nTPM
ovary: 13 nTPM

Single-cell type

esophageal apical cells: 46 nCPM
gastric progenitor cells: 36 nCPM
basal keratinocytes: 31 nCPM
adrenal cortex cells: 31 nCPM
corticotrophs: 30 nCPM
pituicytes/fscs: 30 nCPM

Immune cell

basophil: 8.7 nTPM
MAIT T-cell: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.6 nTPM
naive CD4 T-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM

Brain region

cerebellum: 26 nTPM
choroid plexus: 22 nTPM
thalamus: 21 nTPM
pons: 20 nTPM
midbrain: 20 nTPM
amygdala: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.04
gnomAD missense Z: 1.49
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF12 as an antibody target. Whether an autoantibody or antibody against ZNF12 could matter depends on whether native ZNF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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