Seroatlas · Human Serome Atlas

ZNF117

Zinc finger protein 117

Also known as: H-plk, HPF9, ZN117_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q03924
Gene: ZNF117
Ensembl: ENSG00000152926
Chromosome: 7
Canonical length: 483 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the endogenous retrovirus group 3 member 1 (ERV3-1) and the zinc finger protein 117 (ZNF117) genes on chromosome 7. Readthrough transcripts may encode the same protein as the ZNF117 gene. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>Q03924|ZNF117
     1  MKRHEMVAKH LVMFYYFAQH LWPEQNIRDS FQKVTLRRYR KCGYENLQLR KGCKSVVECK
    61  QHKGDYSGLN QCLKTTLSKI FQCNKYVEVF HKISNSNRHK MRHTENKHFK CKECRKTFCM
   121  LSHLTQHKRI QTRVNFYKCE AYGRAFNWSS TLNKHKRIHT GEKPYKCKEC GKAFNQTSHL
   181  IRHKRIHTEE KPYKCEECGK AFNQSSTLTT HNIIHTGEIP YKCEKCVRAF NQASKLTEHK
   241  LIHTGEKRYE CEECGKAFNR SSKLTEHKYI HTGEKLYKCE ECGKAFNQSS TLTTHKRIHS
   301  GEKPYKCEEC GKAFKQFSNL TDHKKIHTGE KPYKCEECGK AFNQLSNLTR HKVIHTGEKP
   361  YKCGECGKAF NQSSALNTHK IIHTGENPHK CRESGKVFHL SSKLSTCKKI HTGEKLYKCE
   421  ECGKAFNRSS TLIGHKRIHT GEKPYKCEEC GKAFNQSSTL TTHKIIHTEE KQYKCDECGK
   481  AST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF117 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 27 nTPM
adipose tissue: 19 nTPM
breast: 16 nTPM
blood vessel: 12 nTPM
esophagus: 11 nTPM
testis: 11 nTPM

Single-cell type

adipocytes: 315 nCPM
esophageal apical cells: 122 nCPM
neutrophils: 112 nCPM
adrenal cortex cells: 108 nCPM
sertoli cells: 82 nCPM
pituitary stem cells: 60 nCPM

Immune cell

neutrophil: 1.8 nTPM
intermediate monocyte: 0.5 nTPM
memory B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM

Brain region

medulla oblongata: 13 nTPM
midbrain: 13 nTPM
choroid plexus: 12 nTPM
cerebral cortex: 12 nTPM
amygdala: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0.4
gnomAD missense Z: -1.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF117 as an antibody target. Whether an autoantibody or antibody against ZNF117 could matter depends on whether native ZNF117 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF117 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF117 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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