ZNF114
Zinc finger protein 114
Also known as: MGC17986, ZN114_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NC26
- Gene
- ZNF114
- Ensembl
- ENSG00000178150
- Chromosome
- 19
- Canonical length
- 417 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
417 residues, UniProt reviewed canonical sequence.
>Q8NC26|ZNF114
1 MSQDSVTFAD VAVNFTKEEW TLLDPAQRNL YRDVMLENSR NLAFIDWATP CKTKDATPQP
61 DILPKRTFPE ANRVCLTSIS SQHSTLREDW RCPKTEEPHR QGVNNVKPPA VAPEKDESPV
121 SICEDHEMRN HSKPTCRLVP SQGDSIRQCI LTRDSSIFKY NPVLNDSQKT HENNEDDGVL
181 GWNIQWVPCG RKTELKSSTW TGSQNTVHHI RDEIDTGANR HQRNPFGKAF REDGSLRAHN
241 THGREKMYDF TQCENTSRNN SIHAMQMQLY TAETNKKDCQ TGATSANAPN SGSHKSHCTG
301 EKTHKCPECG RAFFYQSFLM RHMKIHTGEK PYECGKCGKA FRYSLHLNKH LRKHVVQKKP
361 YECEECGKVI RESSKYTHIR SHTGEKPYKC KTCGKDFAKS SGLKKHLKTH KDEKPCELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF114 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 5.4 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 5.4 nTPM
- hypothalamus: 1.5 nTPM
- parathyroid gland: 1.5 nTPM
- placenta: 1.3 nTPM
- amygdala: 1.2 nTPM
- cerebral cortex: 1.2 nTPM
Single-cell type
- syncytiotrophoblasts: 53 nCPM
- endometrial luminal cells: 26 nCPM
- migrating cytotrophoblasts: 15 nCPM
- early spermatids: 14 nCPM
- endometrial glandular cells: 9.7 nCPM
- endometrial ciliated cells: 8.2 nCPM
Immune cell
- neutrophil: 2.1 nTPM
- basophil: 1.8 nTPM
- naive B-cell: 1.2 nTPM
- plasmacytoid DC: 1 nTPM
- NK-cell: 0.8 nTPM
- myeloid DC: 0.7 nTPM
Brain region
- cerebellum: 9.6 nTPM
- white matter: 9.5 nTPM
- midbrain: 9.3 nTPM
- cerebral cortex: 9.2 nTPM
- amygdala: 9 nTPM
- hypothalamus: 8.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.85
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.59
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- identical protein binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF114 as an antibody target. Whether an autoantibody or antibody against ZNF114 could matter depends on whether native ZNF114 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF114 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF114 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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