Seroatlas · Human Serome Atlas

ZNF112

Zinc finger protein 112

Also known as: ZFP112, ZN112_HUMAN, ZNF228

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJU3
Gene: ZNF112
Ensembl: ENSG00000062370
Chromosome: 19
Canonical length: 913 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

913 residues, UniProt reviewed canonical sequence.

>Q9UJU3|ZNF112
     1  MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ PFKPDLISQL
    61  EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP KELSSRQTWQ QSAGGLIRCQ
   121  DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH
   181  HSWRKMYLKE SHNYQCRCQQ ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI
   241  MKVSLLNQES IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL
   301  LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE LIHTGEMSYR
   361  HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS CLQVHQKIHT EEKLYTDIEY
   421  GKSFICSSNL DIQHRVHMEE NSYNSEECGN GFSLASHFQD LQIVHTKEQP YKRYVCSNSF
   481  SHNLYLQGHP KIHIGEKPRK EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL
   541  NVHQRVHTGE KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ
   601  RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF NLQIHQRVHT
   661  GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK SFSQRSYLQS HQSVHSGERP
   721  YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE
   781  VCTKGFSESS RLQAHQRVHV EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK
   841  GFSQRSNLQA HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS
   901  SENLHRNEDS VLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF112 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

testis: 7 nTPM
cerebellum: 5.5 nTPM
retina: 4.8 nTPM
parathyroid gland: 4.2 nTPM
breast: 4 nTPM
ovary: 4 nTPM

Single-cell type

choroid plexus epithelial cells: 22 nCPM
bergmann glia: 19 nCPM
oligodendrocytes: 19 nCPM
brain excitatory neurons: 18 nCPM
oligodendrocyte progenitor cells: 18 nCPM
brain inhibitory neurons: 16 nCPM

Immune cell

myeloid DC: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
naive B-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 14 nTPM
spinal cord: 12 nTPM
medulla oblongata: 11 nTPM
hypothalamus: 11 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.01
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF112 as an antibody target. Whether an autoantibody or antibody against ZNF112 could matter depends on whether native ZNF112 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF112 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF112 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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