Seroatlas · Human Serome Atlas

ZNF107

Zinc finger protein 107

Also known as: smap-7, ZFD25, ZN107_HUMAN, ZNF588

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UII5
Gene: ZNF107
Ensembl: ENSG00000196247
Chromosome: 7
Canonical length: 783 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q9UII5|ZNF107
     1  MVAKPPVMSF HFAQDLWPEQ NIKDSFQKVT LRRYGKCEYE NLQLRKGCKH VDECTGHKGG
    61  HNTVNQCLTA TPSKIFQCNK YVKVFDKFSN SNRYKRRHTG NKHFKCKECS KSFCVLSQLT
   121  QHRRIHTRVN SYKCEECGKA FNWFSTLTKH KRIHTGEKPY KCEECGKAFN QSSQLTRHKI
   181  IHTEEKPNKC EECGKAFKQA SHLTIHKIIH TGEKPYKYEE CGKVFSQSSH LTTQKILHTG
   241  ENLYKCKECG KAFNLFSNLT NHKRIHAGEK PYKCKECGRA FNISSNLNKQ EKIHTGGKLN
   301  KCEECDKAFN RSLKLTAHKK ILMEEKPYKC EECGKVFNQF STLTRHKIIH TGEKPYKCKE
   361  CGKAFNQSSN LTEHKKIHTA EKSYKCEECG KAFNQHSNLI NHRKIYSGEK PYKCEECGKA
   421  FNRSSTLTRH KKIHTGEKPY KCEECDRAFS QSSNLTEHKK IHTGEKPYKC EECGKAFNRF
   481  STLTKHKRIH TGEKPYKCEE CGKAFNQSYQ LTRHKIVHTK EKLNKCEEFG KAFKQSSHRT
   541  IHKIIHTGEK PYKCEEHGKV FNQSSNLTTQ KIIHTGENLY KFEEHGKAFN LFSNITNHKI
   601  IYTGEKPHKC EECGKAYNRF SNLTIHKRIH TGEKPYQCAE CGKAFNCSST LNRHKIIHTG
   661  EKPYKCKECG KAFNLSSTLT AHKKIHTGEK PYKCEECGKA FNQSSNLTTH KKIHTSEKPY
   721  KCEECGKSFN QFSSLNIHKI IHTGEKPYKC GDYGRAFNLS SNLTTHKKIH TGEKPYKCEY
   781  GKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF107 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

lymph node: 10 nTPM
thymus: 9.7 nTPM
tonsil: 8.5 nTPM
breast: 5.2 nTPM
spleen: 5.1 nTPM
small intestine: 4.8 nTPM

Single-cell type

b-cells: 109 nCPM
breast lactating cells: 95 nCPM
neutrophils: 64 nCPM
thymocytes: 57 nCPM
t-cells: 56 nCPM
gonadotrophs: 54 nCPM

Immune cell

basophil: 2.9 nTPM
memory B-cell: 2.4 nTPM
neutrophil: 2.4 nTPM
naive B-cell: 2.2 nTPM
naive CD4 T-cell: 2 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

white matter: 3.7 nTPM
medulla oblongata: 3.2 nTPM
spinal cord: 3.1 nTPM
hypothalamus: 3 nTPM
cerebellum: 2.8 nTPM
cerebral cortex: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0.02
gnomAD missense Z: -0.52
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF107 as an antibody target. Whether an autoantibody or antibody against ZNF107 could matter depends on whether native ZNF107 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF107 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF107 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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