Seroatlas · Human Serome Atlas

ZNF101

Zinc finger protein 101

Also known as: DKFZp570I0164, HZF12, ZN101_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZC7
Gene: ZNF101
Ensembl: ENSG00000181896
Chromosome: 19
Canonical length: 436 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q8IZC7|ZNF101
     1  MDSVAFEDVA VNFTQEEWAL LSPSQKNLYR DVTLETFRNL ASVGIQWKDQ DIENLYQNLG
    61  IKLRSLVERL CGRKEGNEHR ETFSQIPDCH LNKKSQTGVK PCKCSVCGKV FLRHSFLDRH
   121  MRAHAGHKRS ECGGEWRETP RKQKQHGKAS ISPSSGARRT VTPTRKRPYE CKVCGKAFNS
   181  PNLFQIHQRT HTGKRSYKCR EIVRAFTVSS FFRKHGKMHT GEKRYECKYC GKPIDYPSLF
   241  QIHVRTHTGE KPYKCKQCGK AFISAGYLRT HEIRSHALEK SHQCQECGKK LSCSSSLHRH
   301  ERTHSGGKLY ECQKCAKVFR CPTSLQAHER AHTGERPYEC NKCGKTFNYP SCFRRHKKTH
   361  SGEKPYECTR CGKAFGWCSS LRRHEMTHTG EKPFDCKQCG KVFTFSNYLR LHERTHLAGR
   421  SQCFGRRQGD HLSPGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

lymph node: 26 nTPM
thymus: 24 nTPM
tonsil: 23 nTPM
bone marrow: 13 nTPM
appendix: 12 nTPM
spleen: 10 nTPM

Single-cell type

esophageal apical cells: 68 nCPM
t-cells: 47 nCPM
b-cells: 25 nCPM
nk-cells: 25 nCPM
thymocytes: 22 nCPM
early primary spermatocytes: 20 nCPM

Immune cell

T-reg: 61 nTPM
naive CD4 T-cell: 44 nTPM
naive CD8 T-cell: 32 nTPM
memory CD4 T-cell: 31 nTPM
MAIT T-cell: 23 nTPM
memory CD8 T-cell: 20 nTPM

Brain region

white matter: 9.1 nTPM
cerebellum: 8.8 nTPM
thalamus: 8.4 nTPM
medulla oblongata: 8.1 nTPM
cerebral cortex: 7.9 nTPM
pons: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.77
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF101 as an antibody target. Whether an autoantibody or antibody against ZNF101 could matter depends on whether native ZNF101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF101 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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