ZNF100

Protein identityUniProt · HPA

UniProt accession

Q8IYN0

Gene

ZNF100

Ensembl

ENSG00000197020

Chromosome

19

Canonical length

542 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8IYN0|ZNF100
     1  MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY
    61  RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE
   121  QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD
   181  PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK
   241  AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR
   301  SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL
   361  TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK
   421  RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT
   481  GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL
   541  QM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF100 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

7.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.63

gnomAD pLI

0

gnomAD missense Z

-0.82

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of DNA-templated transcription

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF100 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28