Seroatlas · Human Serome Atlas

ZNF10

Zinc finger protein 10

Also known as: KOX1, ZNF10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P21506
Gene: ZNF10
Ensembl: ENSG00000256223
Chromosome: 12
Canonical length: 573 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>P21506|ZNF10
     1  MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL VSLGYQLTKP
    61  DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR SIFKDKQSCD IKMEGMARND
   121  LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV
   181  LREYFHKRDS HTKSLKHDLV LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC
   241  PDNDNSLTHG SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK
   301  SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT CNQCGKSFVH
   361  SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV RVRPYECNEC GKSYSQRSHL
   421  VVHHRIHTGL KPFECKDCGK CFSRSSHLYS HQRTHTGEKP YECHDCGKSF SQSSALIVHQ
   481  RIHTGEKPYE CCQCGKAFIR KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT
   541  GEQFLTCNQC GTALVNTSNL IGYQTNHIRE NAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 43 nTPM
epididymis: 22 nTPM
ovary: 21 nTPM
thyroid gland: 20 nTPM
parathyroid gland: 16 nTPM
prostate: 15 nTPM

Single-cell type

other brain neurons: 107 nCPM
choroid plexus epithelial cells: 87 nCPM
brain inhibitory neurons: 74 nCPM
brain excitatory neurons: 70 nCPM
oligodendrocyte progenitor cells: 67 nCPM
astrocytes: 63 nCPM

Immune cell

naive CD4 T-cell: 6.5 nTPM
NK-cell: 6.4 nTPM
memory CD8 T-cell: 4.1 nTPM
memory CD4 T-cell: 3.5 nTPM
plasmacytoid DC: 3.4 nTPM
MAIT T-cell: 3.3 nTPM

Brain region

cerebellum: 21 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 19 nTPM
white matter: 17 nTPM
midbrain: 17 nTPM
choroid plexus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF10 as an antibody target. Whether an autoantibody or antibody against ZNF10 could matter depends on whether native ZNF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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