Seroatlas · Human Serome Atlas

ZMYND15

Zinc finger MYND domain-containing protein 15

Also known as: DKFZp434N127, ZMY15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H091
Gene
ZMYND15
Ensembl
ENSG00000141497
Chromosome
17
Canonical length
742 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

742 residues, UniProt reviewed canonical sequence.

>Q9H091|ZMYND15
     1  MEFVSGYRDE FLDFTALLFG WFRKFVAERG AVGTSLEGRC RQLEAQIRRL PQDPALWVLH
    61  VLPNHSVGIS LGQGAEPGPG PGLGTAWLLG DNPPLHLRDL SPYISFVSLE DGEEGEEEEE
   121  EDEEEEKRED GGAGSTEKVE PEEDRELAPT SRESPQETNP PGESEEAARE AGGGKDGCRE
   181  DRVENETRPQ KRKGQRSEAA PLHVSCLLLV TDEHGTILGI DLLVDGAQGT ASWGSGTKDL
   241  APWAYALLCH SMACPMGSGD PRKPRQLTVG DARLHRELES LVPRLGVKLA KTPMRTWGPR
   301  PGFTFASLRA RTCHVCHRHS FEAKLTPCPQ CSAVLYCGEA CLRADWQRCP DDVSHRFWCP
   361  RLAAFMERAG ELATLPFTYT AEVTSETFNK EAFLASRGLT RGYWTQLSML IPGPGFSRHP
   421  RGNTPSLSLL RGGDPYQLLQ GDGTALMPPV PPHPPRGVFG SWQDYYTWRG LSLDSPIAVL
   481  LTYPLTVYYV ITHLVPQSFP ELNIQNKQSL KIHVVEAGKE FDLVMVFWEL LVLLPHVALE
   541  LQFVGDGLPP ESDEQHFTLQ RDSLEVSVRP GSGISARPSS GTKEKGGRRD LQIKVSARPY
   601  HLFQGPKPDL VIGFNSGFAL KDTWLRSLPR LQSLRVPAFF TESSEYSCVM DGQTMAVATG
   661  GGTSPPQPNP FRSPFRLRAA DNCMSWYCNA FIFHLVYKPA QGSGARPAPG PPPPSPTPSA
   721  PPAPTRRRRG EKKPGRGARR RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • testis: 25 nTPM
  • parathyroid gland: 5.2 nTPM
  • spleen: 5 nTPM
  • lung: 4.4 nTPM
  • duodenum: 3.8 nTPM
  • spinal cord: 3.2 nTPM

Single-cell type

  • early spermatids: 197 nCPM
  • late primary spermatocytes: 156 nCPM
  • neutrophils: 38 nCPM
  • late spermatids: 27 nCPM
  • epididymal basal cells: 26 nCPM
  • cdc: 19 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 4 nTPM
  • thalamus: 3.6 nTPM
  • medulla oblongata: 3.5 nTPM
  • spinal cord: 2.9 nTPM
  • midbrain: 2.8 nTPM
  • pons: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYND15.

Disease | AllUniProt

Conditions ZMYND15 is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.12
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYND15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND15 as an antibody target. Whether an autoantibody or antibody against ZMYND15 could matter depends on whether native ZMYND15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYND15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZMYND15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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