Seroatlas · Human Serome Atlas

ZMYND12

Zinc finger MYND domain-containing protein 12

Also known as: DKFZp434N2435, ZMY12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0C1
Gene: ZMYND12
Ensembl: ENSG00000066185
Chromosome: 1
Canonical length: 365 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in sperm axoneme assembly. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q9H0C1|ZMYND12
     1  MNVIYPLAVP KGRRLCCEVC EAPAERVCAA CTVTYYCGVV HQKADWDSIH EKICQLLIPL
    61  RTSMPFYNSE EERQHGLQQL QQRQKYLIEF CYTIAQKYLF EGKHEDAVPA ALQSLRFRVK
   121  LYGLSSVELV PAYLLLAEAS LGLGRIVQAE EYLFQAQWTV LKSTDCSNAT HSLLHRNLGL
   181  LYIAKKNYEE ARYHLANDIY FASCAFGTED IRTSGGYFHL ANIFYDLKKL DLADTLYTKV
   241  SEIWHAYLNN HYQVLSQAHI QQMDLLGKLF ENDTGLDEAQ EAEAIRILTS ILNIRESTSD
   301  KAPQKTIFVL KILVMFYYLM MNSSKAQEYG MRALSLAKEQ QLDVHEQSTI QELLSLISTE
   361  DHPIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

testis: 27 nTPM
fallopian tube: 16 nTPM
choroid plexus: 9.6 nTPM
epididymis: 8.9 nTPM
kidney: 8.7 nTPM
liver: 6.5 nTPM

Single-cell type

late primary spermatocytes: 249 nCPM
early spermatids: 134 nCPM
late spermatids: 107 nCPM
respiratory ciliated cells: 54 nCPM
fallopian tube ciliated cells: 47 nCPM
epididymal efferent duct ciliated cells: 39 nCPM

Immune cell

NK-cell: 0.7 nTPM
classical monocyte: 0.4 nTPM
myeloid DC: 0.4 nTPM
total PBMC: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

midbrain: 8.7 nTPM
choroid plexus: 5.5 nTPM
medulla oblongata: 5.4 nTPM
hypothalamus: 4.2 nTPM
spinal cord: 4.1 nTPM
pons: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

sperm flagellum

Protein domainsUniProt · Pfam · InterPro

Zinc finger, MYND-type
Tetratricopeptide-like helical domain superfamily
MYND finger
Zinc finger MYND domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND12 as an antibody target. Whether an autoantibody or antibody against ZMYND12 could matter depends on whether native ZMYND12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYND12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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