Seroatlas · Human Serome Atlas

ZMAT5

Zinc finger matrin-type protein 5

Also known as: SNRNP20, ZC3H19, ZMAT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UDW3
Gene: ZMAT5
Ensembl: ENSG00000100319
Chromosome: 22
Canonical length: 170 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q9UDW3|ZMAT5
     1  MGKRYFCDYC DRSFQDNLHN RKKHLNGLQH LKAKKVWYDM FRDAAAILLD EQNKRPCRKF
    61  LLTGQCDFGS NCRFSHMSER DLQELSIQVE EERRAREWLL DAPELPEGHL EDWLEKRAKR
   121  LSSAPSSRAE PIRTTVFQYP VGWPPVQELP PSLRAPPPGG WPLQPRVQWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMAT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 35 nTPM
choroid plexus: 28 nTPM
amygdala: 25 nTPM
liver: 24 nTPM
midbrain: 24 nTPM
spinal cord: 24 nTPM

Single-cell type

esophageal apical cells: 169 nCPM
epididymal principal cells: 104 nCPM
hofbauer cells: 57 nCPM
epididymal efferent duct absorptive cells: 51 nCPM
esophageal suprabasal cells: 48 nCPM
oocytes: 46 nCPM

Immune cell

eosinophil: 96 nTPM
non-classical monocyte: 95 nTPM
intermediate monocyte: 95 nTPM
classical monocyte: 85 nTPM
myeloid DC: 74 nTPM
neutrophil: 70 nTPM

Brain region

medulla oblongata: 19 nTPM
thalamus: 18 nTPM
white matter: 17 nTPM
cerebellum: 16 nTPM
midbrain: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMAT5 as an antibody target. Whether an autoantibody or antibody against ZMAT5 could matter depends on whether native ZMAT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMAT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMAT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...