Seroatlas · Human Serome Atlas

ZMAT4

Zinc finger matrin-type protein 4

Also known as: FLJ13842, ZMAT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H898
Gene: ZMAT4
Ensembl: ENSG00000165061
Chromosome: 8
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q9H898|ZMAT4
     1  MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL
    61  RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK TPLKTTATPL
   121  SPLKPPRMDT APVVASPYQR RDSDRYCGLC AAWFNNPLMA QQHYDGKKHK KNAARVALLE
   181  QLGTTLDMGE LRGLRRNYRC TICSVSLNSI EQYHAHLKGS KHQTNLKNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 15 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 10 nTPM
hippocampal formation: 5.1 nTPM
retina: 4.1 nTPM
hypothalamus: 3.4 nTPM

Single-cell type

retinal amacrine cells: 526 nCPM
retinal ganglion cells: 448 nCPM
brain inhibitory neurons: 395 nCPM
tuft cells: 231 nCPM
other brain neurons: 222 nCPM
thyrotrophs: 165 nCPM

Immune cell

NK-cell: 8.6 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 45 nTPM
pons: 44 nTPM
thalamus: 35 nTPM
basal ganglia: 26 nTPM
medulla oblongata: 24 nTPM
hippocampal formation: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.08
gnomAD missense Z: 1.37
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMAT4 as an antibody target. Whether an autoantibody or antibody against ZMAT4 could matter depends on whether native ZMAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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