Seroatlas · Human Serome Atlas

ZIM2

Zinc finger imprinted 2

Also known as: ZIM2_HUMAN, ZNF656

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZV7
Gene: ZIM2
Ensembl: ENSG00000269699
Chromosome: 19
Canonical length: 527 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>Q9NZV7|ZIM2
     1  MYQPEDDNNS DVTSDDDMTR NRRESSPPHS VHSFSGDRDW DRRGRSRDME PRDRWSHTRN
    61  PRSRMPPRDL SLPVVAKTSF EMDREDDRDS RAYESRSQDA ESYQNVVDLA EDRKPHNTIQ
   121  DNMENYRKLL SLGFLAQDSV PAEKRNTEML DNLPSAGSQF PDFKHLGTFL VFEELVTFED
   181  VLVDFSPEEL SSLSAAQRNL YREVMLENYR NLVSLGHQFS KPDIISRLEE EESYAMETDS
   241  RHTVICQGES HDDPLEPHQG NQEKLLTPIT MNDPKTLTPE RSYGSDEFER SSNLSKQSKD
   301  PLGKDPQEGT APGICTSPQS ASQENKHNRC EFCKRTFSTQ VALRRHERIH TGKKPYECKQ
   361  CAEAFYLMPH LNRHQKTHSG RKTSGCNEGR KPSVQCANLC ERVRIHSQED YFECFQCGKA
   421  FLQNVHLLQH LKAHEAARVL PPGLSHSKTY LIRYQRKHDY VGERACQCCD CGRVFSRNSY
   481  LIQHYRTHTQ ERPYQCQLCG KCFGRPSYLT QHYQLHSQEK TVECDHC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 3 nTPM

Expression across tissuesHPA

Tissue

ovary: 3 nTPM
testis: 3 nTPM
placenta: 1.9 nTPM
retina: 0.8 nTPM
cerebral cortex: 0.6 nTPM
adrenal gland: 0.5 nTPM

Single-cell type

early spermatids: 77 nCPM
retinal horizontal cells: 64 nCPM
late spermatids: 59 nCPM
retinal ganglion cells: 54 nCPM
retinal amacrine cells: 51 nCPM
differentiating spermatogonia: 41 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 14 nTPM
hypothalamus: 13 nTPM
choroid plexus: 12 nTPM
basal ganglia: 10 nTPM
white matter: 9.9 nTPM
midbrain: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZIM2 as an antibody target. Whether an autoantibody or antibody against ZIM2 could matter depends on whether native ZIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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