Seroatlas · Human Serome Atlas

ZIC5

Zinc finger protein ZIC 5

Also known as: ZIC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T25
Gene
ZIC5
Ensembl
ENSG00000139800
Chromosome
13
Canonical length
639 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q96T25|ZIC5
     1  MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP
    61  GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG
   121  AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS
   181  ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH
   241  DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL
   301  HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF
   361  LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH
   421  VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR
   481  SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH
   541  PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY
   601  VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZIC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 27 nTPM
  • choroid plexus: 5.1 nTPM
  • testis: 3.5 nTPM
  • retina: 3.1 nTPM
  • cerebral cortex: 2.2 nTPM
  • hippocampal formation: 1.7 nTPM

Single-cell type

  • bergmann glia: 40 nCPM
  • choroid plexus epithelial cells: 37 nCPM
  • astrocytes: 21 nCPM
  • brain excitatory neurons: 19 nCPM
  • ependymal cells: 15 nCPM
  • early primary spermatocytes: 5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 36 nTPM
  • cerebral cortex: 22 nTPM
  • choroid plexus: 16 nTPM
  • hippocampal formation: 6.8 nTPM
  • basal ganglia: 6.1 nTPM
  • pons: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.77
gnomAD missense Z
0.96
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZIC5 as an antibody target. Whether an autoantibody or antibody against ZIC5 could matter depends on whether native ZIC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZIC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZIC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZIC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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