ZHX1-C8orf76
Zinc fingers and homeoboxes protein 1, isoform 2
Also known as: ZHX1R_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96EF9
- Gene
- ZHX1-C8orf76
- Ensembl
- ENSG00000259305
- Chromosome
- 8
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q96EF9|ZHX1-C8orf76
1 MLRKLWQWFY EETESSDDVE VLTLKKFKGD LAYRRQEYQK ALQEYSSISE KLSSTNFAMK
61 RDVQEGQARC LAHLGRHMEA LEIAANLENK ATNTDHLTTV LYLQLAICSS LQNLEKTIFC
121 LQKLISLHPF NPWNWGKLAE AYLNLGPALS AALASSQKQH SFTSSDKTIK SFFPHSGKDC
181 LLCFPETLPE SSLFSVEANS SNSQKNEKAL TNIQNCMAEK RETVLIETQL KACASFIRTR
241 LLLQFTQPQQ TSFALERNLR TQQEIEDKMK GFSFKEDTLL LIAEVSVSLG FMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZHX1-C8orf76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 8 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 8 nTPM
- choroid plexus: 3.8 nTPM
- skeletal muscle: 3.8 nTPM
- pituitary gland: 3.4 nTPM
- lung: 2.8 nTPM
- spleen: 2.8 nTPM
Single-cell type
- myonuclei: 14 nCPM
- adipocytes: 11 nCPM
- lactotrophs: 10 nCPM
- gonadotrophs: 9.1 nCPM
- thyrotrophs: 8.4 nCPM
- choroid plexus epithelial cells: 7.9 nCPM
Immune cell
- T-reg: 4.9 nTPM
- eosinophil: 4.8 nTPM
- intermediate monocyte: 4.1 nTPM
- non-classical monocyte: 3 nTPM
- classical monocyte: 2.9 nTPM
- naive B-cell: 2.9 nTPM
Brain region
- white matter: 5.6 nTPM
- cerebellum: 5.2 nTPM
- thalamus: 5.1 nTPM
- cerebral cortex: 4.9 nTPM
- medulla oblongata: 4.7 nTPM
- basal ganglia: 4.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.04
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZHX1-C8orf76 as an antibody target. Whether an autoantibody or antibody against ZHX1-C8orf76 could matter depends on whether native ZHX1-C8orf76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZHX1-C8orf76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZHX1-C8orf76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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