Seroatlas · Human Serome Atlas

ZGLP1

GATA-type zinc finger protein 1

Also known as: GATAD3, GLP-1, GLP1, ZGLP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C6A0
Gene: ZGLP1
Ensembl: ENSG00000220201
Chromosome: 19
Canonical length: 273 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

ZGLP1 encodes an evolutionary conserved transcriptional regulator with GATA-like zinc fingers. In females, it is expressed in embryonic germ cells and is essential for oogenic fate determination. It acts downstream of bone morphogenetic protein (BMP) and is involved in the regulation of genes involved in RNA processing, transcription and chromatin modification, retrotransposon regulation, meiotic cell cycle, and oocyte development. In males it is not required for the germ cell sex determination but is required by the spermatogonia for efficiently completing the meiotic prophase. [provided by RefSeq, Jul 2022]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>P0C6A0|ZGLP1
     1  MEAEPIPDSS MPAKLLAPPC LNLERLGGSP SQEKPRTPGC CRISERSLWP ACQESVTALC
    61  FLQETVERLG QSPAQDTPVL GPCWDPMALG TQGRLLLDRD SKDTQTRISQ KGRRLQPPGT
   121  PSAPPQRRPR KQLNPCRGTE RVDPGFEGVT LKFQIKPDSS LQIIPTYSLP CSSRSQESPA
   181  DAVGGPAAHP GGTEAHSAGS EALEPRRCAS CRTQRTPLWR DAEDGTPLCN ACGIRYKKYG
   241  TRCSSCWLVP RKNVQPKRLC GRCGVSLDPI QEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZGLP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 9.8 nTPM
thyroid gland: 9 nTPM
pituitary gland: 8.3 nTPM
kidney: 7.8 nTPM

Single-cell type

megakaryocytes: 50 nCPM
platelets: 27 nCPM
differentiating spermatogonia: 19 nCPM
kupffer cells: 18 nCPM
undifferentiated spermatogonia: 16 nCPM
monocytes: 9.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 7.9 nTPM
hippocampal formation: 5.8 nTPM
basal ganglia: 5.2 nTPM
white matter: 4.8 nTPM
amygdala: 4.5 nTPM
cerebellum: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.39
gnomAD missense Z: 1.25
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZGLP1 as an antibody target. Whether an autoantibody or antibody against ZGLP1 could matter depends on whether native ZGLP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZGLP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZGLP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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