Seroatlas · Human Serome Atlas

ZG16B

Pancreatic adenocarcinoma up-regulated factor

Also known as: HRPE773, JCLN2, PAUF_HUMAN, PRO1567

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DA0
Gene: ZG16B
Ensembl: ENSG00000162078
Chromosome: 16
Canonical length: 172 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Vesicles
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. Involved in cell migration. Located in apicolateral plasma membrane; cytoplasm; and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q96DA0|ZG16B
     1  MLLLLTLALL GGPTWAGKMY GPGGGKYFST TEDYDHEITG LRVSVGLLLV KSVQVKLGDS
    61  WDVKLGALGG NTQEVTLQPG EYITKVFVAF QAFLRGMVMY TSKDRYFYFG KLDGQISSAY
   121  PSQEGQVLVG IYGQYQLLGI KSIGFEWNYP LEEPTTEPPV NLTYSANSPV GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZG16B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 80,767 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 80,767 nTPM
pancreas: 98 nTPM
prostate: 98 nTPM
gallbladder: 71 nTPM
cervix: 69 nTPM
breast: 56 nTPM

Single-cell type

salivary acinar cells: 453 nCPM
salivary myoepithelial cells: 97 nCPM
lacrimal acinar cells: 78 nCPM
submucosal glandular cells: 22 nCPM
endometrial secretory cells: 20 nCPM
mucous neck cells: 17 nCPM

Immune cell

non-classical monocyte: 9.3 nTPM
intermediate monocyte: 8.1 nTPM
classical monocyte: 1.9 nTPM
total PBMC: 1.1 nTPM
basophil: 0.6 nTPM
myeloid DC: 0.5 nTPM

Brain region

pons: 0.3 nTPM
midbrain: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

carbohydrate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZG16B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MUC7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZG16B as an antibody target. Whether an autoantibody or antibody against ZG16B could matter depends on whether native ZG16B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZG16B is annotated at the cell surface, where native ZG16B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZG16B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...