Seroatlas · Human Serome Atlas

ZG16

Zymogen granule membrane protein 16

Also known as: hZG16, JCLN, JCLN1, ZG16_HUMAN, ZG16A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60844
Gene: ZG16
Ensembl: ENSG00000174992
Chromosome: 16
Canonical length: 167 aa
Protein class: Predicted secreted proteins
Subcellular location: Mid piece,Principal piece,Annulus
Secretome location: Secreted to digestive system

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity and peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in Golgi lumen and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>O60844|ZG16
     1  MLTVALLALL CASASGNAIQ ARSSSYSGEY GGGGGKRFSH SGNQLDGPIT ALRVRVNTYY
    61  IVGLQVRYGK VWSDYVGGRN GDLEEIFLHP GESVIQVSGK YKWYLKKLVF VTDKGRYLSF
   121  GKDSGTSFNA VPLHPNTVLR FISGRSGSLI DAIGLHWDVY PSSCSRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZG16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 449 nTPM

Expression across tissuesHPA

Tissue

rectum: 449 nTPM
colon: 340 nTPM
small intestine: 137 nTPM
duodenum: 54 nTPM
liver: 21 nTPM
smooth muscle: 12 nTPM

Single-cell type

goblet cells: 48,497 nCPM
enterocytes: 929 nCPM
colonocytes: 831 nCPM
enteric transient amplifying cells: 155 nCPM
neuroendocrine cells: 82 nCPM
hepatocytes: 58 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
basal ganglia: 1.2 nTPM
cerebral cortex: 1.1 nTPM
hippocampal formation: 1.1 nTPM
midbrain: 1 nTPM
thalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.62
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

defense response to Gram-positive bacterium
protein transport
suppression of symbiont entry into host

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZG16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBQLN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZG16 as an antibody target. Whether an autoantibody or antibody against ZG16 could matter depends on whether native ZG16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZG16 is annotated as secreted, so native ZG16 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ZG16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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