Seroatlas · Human Serome Atlas

ZFYVE19

Abscission/NoCut checkpoint regulator

Also known as: ANCHR, ANCHR_HUMAN, FLJ14840, MPFYVE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96K21
Gene
ZFYVE19
Ensembl
ENSG00000166140
Chromosome
15
Canonical length
471 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol-3-phosphate binding activity. Involved in midbody abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q96K21|ZFYVE19
     1  MNYDSQQPPL PPLPYAGCRR ASGFPALGRG GTVPVGVWGG AGQGREGRSW GEGPRGPGLG
    61  RRDLSSADPA VLGATMESRC YGCAVKFTLF KKEYGCKNCG RAFCSGCLSF SAAVPRTGNT
   121  QQKVCKQCHE VLTRGSSANA SKWSPPQNYK KRVAALEAKQ KPSTSQSQGL TRQDQMIAER
   181  LARLRQENKP KLVPSQAEIE ARLAALKDER QGSIPSTQEM EARLAALQGR VLPSQTPQPA
   241  HHTPDTRTQA QQTQDLLTQL AAEVAIDESW KGGGPAASLQ NDLNQGGPGS TNSKRQANWS
   301  LEEEKSRLLA EAALELREEN TRQERILALA KRLAMLRGQD PERVTLQDYR LPDSDDDEDE
   361  ETAIQRVLQQ LTEEASLDEA SGFNIPAEQA SRPWTQPRGA EPEAQDVDPR PEAEEEELPW
   421  CCICNEDATL RCAGCDGDLF CARCFREGHD AFELKEHQTS AYSPPRAGQE H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFYVE19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 26 nTPM
  • liver: 18 nTPM
  • midbrain: 16 nTPM
  • cerebellum: 15 nTPM
  • esophagus: 15 nTPM
  • parathyroid gland: 13 nTPM

Single-cell type

  • esophageal apical cells: 128 nCPM
  • cytotrophoblasts: 95 nCPM
  • migrating cytotrophoblasts: 76 nCPM
  • syncytiotrophoblasts: 67 nCPM
  • cardiomyocytes: 67 nCPM
  • enterocytes: 53 nCPM

Immune cell

  • intermediate monocyte: 9.4 nTPM
  • basophil: 9.1 nTPM
  • NK-cell: 8.9 nTPM
  • myeloid DC: 6.5 nTPM
  • MAIT T-cell: 6.2 nTPM
  • non-classical monocyte: 6.2 nTPM

Brain region

  • medulla oblongata: 28 nTPM
  • cerebellum: 27 nTPM
  • pons: 26 nTPM
  • thalamus: 24 nTPM
  • midbrain: 22 nTPM
  • white matter: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFYVE19.

Disease | AllUniProt

Conditions ZFYVE19 is implicated in, by any mechanism.

  • Cholestasis, progressive familial intrahepatic, 9 (PFIC9) MIM:619849

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cholestasis, progressive familial intrahepatic, 9
  • ZFYVE19-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFYVE19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFYVE19 as an antibody target. Whether an autoantibody or antibody against ZFYVE19 could matter depends on whether native ZFYVE19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFYVE19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFYVE19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFYVE19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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