Seroatlas · Human Serome Atlas

ZFY

Zinc finger Y-chromosomal protein

Also known as: ZFY_HUMAN, ZNF911

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08048
Gene: ZFY
Ensembl: ENSG00000067646
Chromosome: Y
Canonical length: 801 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

801 residues, UniProt reviewed canonical sequence.

>P08048|ZFY
     1  MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI TVHNFVPDDP
    61  DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL DSDVTEEVSL PHCTVPDDVL
   121  ASDITSTSMS MPEHVLTSES MHVCDIGHVE HMVHDSVVEA EIITDPLTSD IVSEEVLVAD
   181  CAPEAVIDAS GISVDQQDND KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD
   241  STCPEVIKVY IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN
   301  DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT FVPIAWAAAY
   361  GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP DSRQYQTAII IGPDGHPLTV
   421  YPCMICGKKF KSRGFLKRHM KNHPEHLAKK KYHCTDCDYT TNKKISLHNH LESHKLTSKA
   481  EKAIECDECG KHFSHAGALF THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK
   541  NFPHICVECG KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP
   601  FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS VHTKDYPHKC
   661  EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV LSRHILSVHT KDLPFRCKRC
   721  RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY STTDASGFKR HVISIHTKDY PHRCEYCKKG
   781  FRRPSEKNQH IMRHHKEVGL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 7.5 nTPM
tongue: 6.9 nTPM
testis: 6.7 nTPM
prostate: 4.7 nTPM
rectum: 4.7 nTPM
esophagus: 4.3 nTPM

Single-cell type

late spermatids: 162 nCPM
choroid plexus epithelial cells: 81 nCPM
hematopoietic stem cells: 65 nCPM
bergmann glia: 61 nCPM
oligodendrocyte progenitor cells: 61 nCPM
pituicytes/fscs: 60 nCPM

Immune cell

MAIT T-cell: 3.1 nTPM
myeloid DC: 2.9 nTPM
NK-cell: 2.9 nTPM
classical monocyte: 2.7 nTPM
naive CD4 T-cell: 2.7 nTPM
memory CD4 T-cell: 2.5 nTPM

Brain region

cerebellum: 8.2 nTPM
choroid plexus: 4.8 nTPM
white matter: 4.8 nTPM
hypothalamus: 4.3 nTPM
medulla oblongata: 4.3 nTPM
midbrain: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.69
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.46
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

L3MBTL2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFY as an antibody target. Whether an autoantibody or antibody against ZFY could matter depends on whether native ZFY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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