Seroatlas · Human Serome Atlas

ZFTA

Zinc finger translocation-associated protein

Also known as: C11orf95, MGC3032, ZFTA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JLR9
Gene: ZFTA
Ensembl: ENSG00000188070
Chromosome: 11
Canonical length: 678 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>C9JLR9|ZFTA
     1  MEPGGDHRSR SSGGRGGPGP AVASARGRRL PPAGSSGSAE PEEDEGGQDL QLEGGALGSW
    61  GSAPLPSSRA RGPASSGRKY SDHCEARASR PGKSRIPGRD HRRYYHDHWR LEYLMDFNPA
   121  RHGMVCMVCG SSLATLKLST IKRHIRQKHP YSLHWSPREK EVISNSWDAH LGLGACGEAE
   181  GLGVQGAEEE EEEEEEEEEE GAGVPACPPK GPGKAPAGGG CRRQRRGGPV APRARRLRLS
   241  ASRRAGGSRG LGARRLERRL KESLQNWFRA ECLMDYDPRG NRLVCMACGR ALPSLHLDDI
   301  RAHVLEVHPG SLGLSGPQRS ALLQAWGGQP EALSELTQSP PGDDLAPQDL TGKSRDSASA
   361  AGAPSSQDLS PPDVKEEAGW VPERPGPAEE EEELEEGEGE RAGVPGRSPR GRAHRRHPQE
   421  RWRLEYLMEL DGGRRGLVCG VCGGALASLK MSTIERHIRR RHPGSTRLGG PVQALIAREW
   481  SEKAAHLLAL GPPRPESPQG PIPPGTAAAS DEGGGDEEEE PEEEEEEWGD VPLSPGAPLE
   541  RPAEEEEDEE DGQEPGGLAL PPPPPPPPPP PPRSREQRRN YQPRWRGEYL MDYDGSRRGL
   601  VCMVCGGALA TLKVSTIKRH ILQVHPFSMD FTPEERQTIL EAYEEAALRC YGHEGFGPPA
   661  PAPRDGGADL KSGAVCRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
endometrium: 19 nTPM
cervix: 17 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 14 nTPM

Single-cell type

tuft cells: 23 nCPM
hepatic stellate cells: 19 nCPM
leydig cells: 19 nCPM
corticotrophs: 16 nCPM
epicardial cells: 14 nCPM
pericytes: 14 nCPM

Immune cell

NK-cell: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 39 nTPM
hippocampal formation: 37 nTPM
hypothalamus: 35 nTPM
amygdala: 31 nTPM
basal ganglia: 31 nTPM
midbrain: 22 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFTA as an antibody target. Whether an autoantibody or antibody against ZFTA could matter depends on whether native ZFTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFTA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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