Seroatlas · Human Serome Atlas

ZFP92

Zinc finger protein 92 homolog

Also known as: ZFP92_HUMAN, ZNF897

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM28
Gene: ZFP92
Ensembl: ENSG00000189420
Chromosome: X
Canonical length: 416 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>A6NM28|ZFP92
     1  MAAILLTTRP KVPVSFEDVS VYFTKTEWKL LDLRQKVLYK RVMLENYSHL VSLGFSFSKP
    61  HLISQLERGE GPWVADIPRT WATAGLHIGD RTQSKTSTST QKHSGRQLPG ADPQGGKEGQ
   121  AARSSVLQRG AQGLGQSSAA GPQGPKGAEK RYLCQQCGKA FSRSSNLIKH RIIHSGEKPY
   181  ACPECGKLFR RSFALLEHQR IHSGEKPYAC PECSKTFTRS SNLIKHQVIH SGERPFACGD
   241  CGKLFRRSFA LLEHARVHSG ERPYACPECG KAFSRSSNLI EHQRTHRGEK PYACGQCAKA
   301  FKGVSQLIHH QRSHSGERPF ACRECGKAFR GRSGLSQHRR VHSGEKPYEC SDCGKAFGRR
   361  ANLFKHQAVH GARRPAKAET ARRLAGPGST GPGSAVAATS PPRPSTAARP SRPSRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 3.9 nTPM
ovary: 3.7 nTPM
cerebellum: 3.2 nTPM
fallopian tube: 2.9 nTPM
bone marrow: 2.7 nTPM
pituitary gland: 2.4 nTPM

Single-cell type

gonadotrophs: 12 nCPM
endometrial luminal cells: 8.2 nCPM
neutrophil progenitors: 8 nCPM
pericytes: 7.9 nCPM
decidual stromal cells: 7.5 nCPM
megakaryocytes: 6.2 nCPM

Immune cell

intermediate monocyte: 0.2 nTPM
gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 7.5 nTPM
cerebellum: 7.4 nTPM
choroid plexus: 7.4 nTPM
thalamus: 7 nTPM
basal ganglia: 6.5 nTPM
pons: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.65
gnomAD missense Z: 2.05
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP92 as an antibody target. Whether an autoantibody or antibody against ZFP92 could matter depends on whether native ZFP92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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