Seroatlas · Human Serome Atlas

ZFP90

Zinc finger protein 90 homolog

Also known as: KIAA1954, NK10, ZFP90_HUMAN, ZNF756

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF47
Gene: ZFP90
Ensembl: ENSG00000184939
Chromosome: 16
Canonical length: 636 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles,Plasma membrane,Centrosome

OverviewNCBI Gene

This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q8TF47|ZFP90
     1  MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL VSLGYQVSKP
    61  EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ DVSEVSHCTH DLLHATLEDS
   121  WDVSSQLDRQ QENWKRHLGS EASTQKKIIT PQENFEQNKF GENSRLNTNL VTQLNIPARI
   181  RPSECETLGS NLGHNADLLN ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP
   241  NGTDQGIYPG KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH
   301  ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG TSLTQHEVTH
   361  SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG RAFGQSPSLY KHMRIHKRGK
   421  PYQSSNYSID FKHSTSLTQD ESTLTEVKSY HCNDCGEDFS HITDFTDHQR IHTAENPYDC
   481  EQAFSQQAIS HPGEKPYQCN VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL
   541  TQHERTHTGE KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ
   601  RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 15 nTPM
cerebellum: 15 nTPM
parathyroid gland: 15 nTPM
spinal cord: 14 nTPM
ovary: 14 nTPM
midbrain: 13 nTPM

Single-cell type

retinal ganglion cells: 81 nCPM
differentiating spermatogonia: 77 nCPM
retinal horizontal cells: 66 nCPM
other brain neurons: 66 nCPM
gonadotrophs: 65 nCPM
retinal amacrine cells: 65 nCPM

Immune cell

basophil: 7.8 nTPM
MAIT T-cell: 6.7 nTPM
naive CD4 T-cell: 6.6 nTPM
memory CD8 T-cell: 5.9 nTPM
naive CD8 T-cell: 5.8 nTPM
T-reg: 5.8 nTPM

Brain region

cerebellum: 81 nTPM
cerebral cortex: 66 nTPM
white matter: 65 nTPM
amygdala: 64 nTPM
basal ganglia: 62 nTPM
hypothalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.03
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP90 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP90 as an antibody target. Whether an autoantibody or antibody against ZFP90 could matter depends on whether native ZFP90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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