Seroatlas · Human Serome Atlas

ZFP82

Zinc finger protein 82 homolog

Also known as: KIAA1948, MGC45380, ZFP82_HUMAN, ZNF545

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N141
Gene
ZFP82
Ensembl
ENSG00000181007
Chromosome
19
Canonical length
532 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>Q8N141|ZFP82
     1  MALRSVMFSD VSIDFSPEEW EYLDLEQKDL YRDVMLENYS NLVSLGCFIS KPDVISSLEQ
    61  GKEPWKVVRK GRRQYPDLET KYETKKLSLE NDIYEINLSQ WKIMERIENH GLKGLILKND
   121  WESTGKIEGQ ERPQEGYFSS VKMPSEKVSS YQKRTSVTPH QRLHFVDKPY ECKECGKAFR
   181  VRQQLTFHHR IHTGEKPYEC KECGMAFRQT AHLTRHQRLH SGEKLYECKE CGEAFICGAD
   241  LRVHQKMHIG EKPYECKECG KAFRVRGQLT LHQRIHTGEK PYVCKECGKA FRQYAHLTRH
   301  QKLNSADRLY ECKECGKAFL CGSGLRVHHK LHTGEKPYEC KECGKAFRVR QQLTLHQRIH
   361  TGEKPYECKE CGKTFSRGYH LILHHRIHTG EKPYECKECW KAFSRYSQLI SHQSIHIGVK
   421  PYDCKECGKA FRLLSQLTQH QSIHIGEKPY KCKECGKAFR LRQKLTLHQS IHTGEKPFEC
   481  KECRKAFRLN SSLIQHLRIH SGEKPYECKE CKKAFRQHSH LTHHLKIHNV KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
4.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 4.7 nTPM
  • retina: 4.7 nTPM
  • epididymis: 4 nTPM
  • ovary: 3.8 nTPM
  • thyroid gland: 3.8 nTPM
  • cerebral cortex: 3.5 nTPM

Single-cell type

  • bergmann glia: 38 nCPM
  • oligodendrocyte progenitor cells: 36 nCPM
  • oligodendrocytes: 36 nCPM
  • early primary spermatocytes: 33 nCPM
  • retinal amacrine cells: 32 nCPM
  • lactotrophs: 31 nCPM

Immune cell

  • memory B-cell: 4.9 nTPM
  • naive B-cell: 4.3 nTPM
  • naive CD4 T-cell: 4 nTPM
  • naive CD8 T-cell: 3.6 nTPM
  • memory CD8 T-cell: 3 nTPM
  • gdT-cell: 2.7 nTPM

Brain region

  • cerebellum: 12 nTPM
  • cerebral cortex: 9.6 nTPM
  • basal ganglia: 8.9 nTPM
  • hypothalamus: 8.7 nTPM
  • white matter: 8.7 nTPM
  • hippocampal formation: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.58
gnomAD missense Z
1.85
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP82 as an antibody target. Whether an autoantibody or antibody against ZFP82 could matter depends on whether native ZFP82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFP82. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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