Seroatlas · Human Serome Atlas

ZFP57

Zinc finger protein 57 homolog

Also known as: bA145L22, bA145L22.2, C6orf40, ZFP57_HUMAN, ZNF698

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NU63
Gene: ZFP57
Ensembl: ENSG00000204644
Chromosome: 6
Canonical length: 452 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q9NU63|ZFP57
     1  MAAGEPRSLL FFQKPVTFED VAVNFTQEEW DCLDASQRVL YQDVMSETFK NLTSVARIFL
    61  HKPELITKLE QEEEQWRETR VLQASQAGPP FFCYTCGKCF SRRSYLYSHQ FVHNPKLTNS
   121  CSQCGKLFRS PKSLSYHRRM HLGERPFCCT LCDKTYCDAS GLSRHRRVHL GYRPHSCSVC
   181  GKSFRDQSEL KRHQKIHQNQ EPVDGNQECT LRIPGTQAEF QTPIARSQRS IQGLLDVNHA
   241  PVARSQEPIF RTEGPMAQNQ ASVLKNQAPV TRTQAPITGT LCQDARSNSH PVKPSRLNVF
   301  CCPHCSLTFS KKSYLSRHQK AHLTEPPNYC FHCSKSFSSF SRLVRHQQTH WKQKSYLCPI
   361  CDLSFGEKEG LMDHWRGYKG KDLCQSSHHK CRVILGQWLG FSHDVPTMAG EEWKHGGDQS
   421  PPRIHTPRRR GLREKACKGD KTKEAVSILK HK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 18 nTPM
midbrain: 11 nTPM
heart muscle: 8.3 nTPM
hippocampal formation: 6.6 nTPM
basal ganglia: 5.7 nTPM
amygdala: 4.9 nTPM

Single-cell type

renal collecting duct intercalated cells: 11 nCPM
oligodendrocytes: 4.2 nCPM
microglia: 1.7 nCPM
oligodendrocyte progenitor cells: 1.5 nCPM
monocytes: 0.6 nCPM
hematopoietic stem cells: 0.5 nCPM

Immune cell

basophil: 11 nTPM
myeloid DC: 2.1 nTPM
gdT-cell: 1.7 nTPM
T-reg: 1.5 nTPM
classical monocyte: 1.4 nTPM
NK-cell: 1.3 nTPM

Brain region

white matter: 2.2 nTPM
medulla oblongata: 1.7 nTPM
basal ganglia: 1.2 nTPM
pons: 1.2 nTPM
cerebral cortex: 1 nTPM
cerebellum: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFP57.

Disease | AllUniProt

Conditions ZFP57 is implicated in, by any mechanism.

Diabetes mellitus, transient neonatal, 1 (TNDM1) MIM:601410

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Diabetes mellitus, transient neonatal, 1
ZFP57-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP57 as an antibody target. Whether an autoantibody or antibody against ZFP57 could matter depends on whether native ZFP57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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