Seroatlas · Human Serome Atlas

ZFP42

Zinc finger protein 42 homolog

Also known as: REX1, ZFP42_HUMAN, ZNF754

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MM3
Gene: ZFP42
Ensembl: ENSG00000179059
Chromosome: 4
Canonical length: 310 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q96MM3|ZFP42
     1  MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC DGYVCYEPGP
    61  QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK GSEQQLSQKV FEASSLECSL
   121  EYMKKGVKKE LPQKIVGENS LEYSEYMTGK KLPPGGIPGI DLSDPKQLAE FARKKPPINK
   181  EYDSLSAIAC PQSGCTRKLR NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT
   241  GEKPFRCTFE GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
   301  NTNKNEQEGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 2 nTPM

Expression across tissuesHPA

Tissue

testis: 2 nTPM
placenta: 0.6 nTPM
skeletal muscle: 0.6 nTPM
skin: 0.5 nTPM
bone marrow: 0.4 nTPM
lung: 0.4 nTPM

Single-cell type

early spermatids: 75 nCPM
extravillous trophoblasts: 73 nCPM
migrating cytotrophoblasts: 37 nCPM
cytotrophoblasts: 15 nCPM
late spermatids: 14 nCPM
syncytiotrophoblasts: 9.3 nCPM

Immune cell

basophil: 1.6 nTPM
neutrophil: 1.4 nTPM
NK-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
memory B-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

white matter: 5.1 nTPM
cerebral cortex: 4.4 nTPM
medulla oblongata: 4.3 nTPM
cerebellum: 4.2 nTPM
choroid plexus: 4 nTPM
thalamus: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.45
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP42 as an antibody target. Whether an autoantibody or antibody against ZFP42 could matter depends on whether native ZFP42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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