ZFP41
Zinc finger protein 41 homolog
Also known as: FLJ00028, FLJ38705, ZFP41_HUMAN, ZNF753
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8Y5
- Gene
- ZFP41
- Ensembl
- ENSG00000181638
- Chromosome
- 8
- Canonical length
- 198 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Nucleoli rim,Plasma membrane
OverviewNCBI Gene
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
198 residues, UniProt reviewed canonical sequence.
>Q8N8Y5|ZFP41
1 MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP CLSPEDEEHV
61 FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT DHIRHQRVHT GEKPFKCAQC
121 GKAFRHSSDV TKHQRTHTGE KPFKCGECGK AFNCGSNLLK HQKTHTGEKP YECTHCGKAF
181 AYSSCLIRHQ KRHPRKKPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZFP41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 6.8 nTPM
Expression across tissuesHPA
Tissue
- hypothalamus: 6.8 nTPM
- cerebral cortex: 6.1 nTPM
- testis: 6 nTPM
- cerebellum: 5.3 nTPM
- hippocampal formation: 5.2 nTPM
- amygdala: 5.1 nTPM
Single-cell type
- ependymal cells: 12 nCPM
- choroid plexus epithelial cells: 10 nCPM
- oligodendrocytes: 7.6 nCPM
- astrocytes: 6.3 nCPM
- microglia: 6.3 nCPM
- bergmann glia: 6 nCPM
Immune cell
- plasmacytoid DC: 0.9 nTPM
- MAIT T-cell: 0.5 nTPM
- naive CD4 T-cell: 0.4 nTPM
- gdT-cell: 0.3 nTPM
- naive CD8 T-cell: 0.3 nTPM
- intermediate monocyte: 0.2 nTPM
Brain region
- white matter: 38 nTPM
- cerebral cortex: 38 nTPM
- thalamus: 35 nTPM
- medulla oblongata: 35 nTPM
- hypothalamus: 32 nTPM
- basal ganglia: 32 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.82
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.26
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZFP41 as an antibody target. Whether an autoantibody or antibody against ZFP41 could matter depends on whether native ZFP41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZFP41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZFP41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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