ZFP30
Zinc finger protein 30 homolog
Also known as: KIAA0961, ZFP30_HUMAN, ZNF745
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2G7
- Gene
- ZFP30
- Ensembl
- ENSG00000120784
- Chromosome
- 19
- Canonical length
- 519 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
519 residues, UniProt reviewed canonical sequence.
>Q9Y2G7|ZFP30
1 MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI SKPDVITLLE
61 QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL SQWKVMERIK SCGLEEQESP
121 HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK SHNREKPYEC GECGKAFRVR QQLTFHQRIH
181 TGEKPYECKE CGKAFRQCAH LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK
241 PYECKECGKA FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC
301 KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG EKPYDCKECG
361 KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH QGIHIGEKPY ECKECGKAFR
421 LFSQLTQHQS IHFGEKPFKC KECEKTFRLL SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS
481 LIQHQRIHSG EKPYKCKECK KAFRQHSHLT YHQRIHNVTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZFP30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 8.7 nTPM
Expression across tissuesHPA
Tissue
- retina: 8.7 nTPM
- testis: 7.6 nTPM
- ovary: 6.3 nTPM
- thyroid gland: 6 nTPM
- parathyroid gland: 5.8 nTPM
- cerebral cortex: 5.3 nTPM
Single-cell type
- early spermatids: 131 nCPM
- pdcs: 70 nCPM
- thyrotrophs: 65 nCPM
- cardiomyocytes: 62 nCPM
- retinal bipolar cells: 57 nCPM
- retinal amacrine cells: 50 nCPM
Immune cell
- NK-cell: 3 nTPM
- naive CD4 T-cell: 2.4 nTPM
- naive CD8 T-cell: 2.4 nTPM
- naive B-cell: 2.3 nTPM
- basophil: 2.2 nTPM
- MAIT T-cell: 2 nTPM
Brain region
- cerebellum: 33 nTPM
- white matter: 22 nTPM
- cerebral cortex: 20 nTPM
- hypothalamus: 19 nTPM
- basal ganglia: 19 nTPM
- thalamus: 18 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ZFP30.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 73 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.92
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZFP30 as an antibody target. Whether an autoantibody or antibody against ZFP30 could matter depends on whether native ZFP30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZFP30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZFP30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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